中药鬼针草化学成分的研究  

Studies on Chemical Constituents of Bidens Bipinnata

作　　者：杨小唯[1] 黄敏珠[2] 赵卫权 金永生 陈海生 

机构地区：[1]第二军医大学药学院天然药物化学教研室,上海200433 [2]解放军第117医院药剂科,浙江杭州310012 [3]不详

出　　处：《解放军药学学报》2009年第4期283-286,共4页Pharmaceutical Journal of Chinese People's Liberation Army

基　　金：上海市重点学科建设资助项目;No.B906

摘　　要：目的研究鬼针草的化学成分。方法采用80%乙醇渗漉提取,硅胶、SephadexLH-20等柱层析方法进行分离纯化,通过化学反应和光谱方法鉴定其化学结构。结果从鬼针草中得到3,5-双咖啡酰奎宁酸甲酯(1),奥卡宁4'-O-β-D-(2'',4'',6''-三乙酰基)-葡萄糖苷(2),3',4'-二甲氧基槲皮素(3),3,5-二羟基-3',5'-二甲氧基黄酮-7-O-β-D-吡喃葡萄糖苷(4),7,8,3',4'-四羟基二氢黄酮醇(5),7,8-二羟基香豆素(6),5,8,4'-三羟基黄酮-7-O-β-D-葡萄糖苷(7)。结论以上化合物均为首次从鬼针草属中分离得到。im To study the chemical constituents of Bidens bipinnata L.Methods The dried whole plant was extracted with 80% EtOH.Isolation and purification were carried out on silica gel,C18 silica gel,Sephadex LH-20 column chromatography.The structures were elucidated on the basis of spectral and chemical studies.Results Seven compounds were obtained from Bidens bipinnata,and their chemical structures were identified as：3,5-di-O-caffeoylquinic acid methyl ester（1）,Okanin 4＇-O-β-D-（2＇＇,4＇＇,6＇＇-triacetyl）-glucopyranoside（2）,3＇,4＇-dimethoxyhyperoside（3）,3,5-dihydroxy-3＇,5＇-dimethoxyflavon-7-O-β-D-glucopyranoside（4）,7,8,3＇,4＇-tetraflavanonol（5）,7,8-dihydroxycoumarin（6）,5,8,4＇-trihydroxy-7-O-β-D-glucopyranoside（7）.Conclusion All these compounds were obtained from this plant for the first time.

关 键 词：鬼针草 化学成分 黄酮类 

分 类 号：R284[医药卫生—中药学]