应用二维谱学技术归属泰妥拉唑的~1H和^(13)C NMR(英文)  

~1H and ^(13)C NMR Chemical Shift Assignment for Tenatoprazole

作　　者：林振广[1] 林吉茂[1] 扈占坤[1] 曹珍艳[1] 

机构地区：[1]山东大学化学与化工学院,山东济南250100

出　　处：《波谱学杂志》2009年第3期393-399,共7页Chinese Journal of Magnetic Resonance

摘　　要：应用DEPT(无畸变极化转移增强谱)、HMQC(异核多量子相干谱)、HMBC(异核多键相干谱)、1H-1HCOSY(相关谱)、NOESY(核欧沃豪斯谱)和TOCSY(全相关谱)谱学技术,对泰妥拉唑所有的氢进行了归属.不对称硫原子引起邻接CH22个氢化学位移不等价;该2个氢相互偶合,其偶合常数为12.9 Hz;借助DEPT谱,2个甲氧基被区别;借助DEPT和TOCSY谱,另2个与碳相连的甲基被区分;利用HMBC谱,所有的碳峰可以归属.Tenatoprazole is a novel proton pump inhibitor currently undergoing phase III clinical trail. In this study, the ^1H and ^13C chemical shifts of this compound were assigned using 2D NMR techniques, including DEPT, HMQC, HMBC, COSY, NOESY and TOCSY. The asymmetric structure of the compound was elucidated by NOESY. All quaternary carbons of the compound were also assigned by HMBC.

关 键 词：NMR 归属 2D NMR 泰妥拉唑 

分 类 号：O482.53[理学—固体物理]