NMR在天然产物选择性分离与结构研究中的应用  

NMR Application in Selective Separation for Natural Products and Their Structural Investigation

作　　者：耿珠峰[1] 欧阳捷[1] 邓志威[1] 沈圣民[2] 杜树山[2] 

机构地区：[1]北京师范大学分析测试中心,北京100875 [2]北京师范大学资源学院教育部资源药物工程研究中心,北京100875

出　　处：《波谱学杂志》2009年第3期424-436,共13页Chinese Journal of Magnetic Resonance

摘　　要：核磁共振(NMR)是天然产物化学研究的重要手段.本工作将核磁共振技术作为选择性提取分离的监测手段,依据目标化合物的NMR谱学特征,以1H NMR监控和指导从植物体中寻找和得到二萜类化合物收到了较好的效果.并运用多种核磁共振技术对分离得到的3种二萜类化合物(jolkinolide A、jolkinolide B和17-hydro-xyjolkinolide B)进行了结构解析.NMR has played an important role in Natural Product Chemistry. In this work, NMR technique was used as a valid monitor in the separation process of natural products, in addition to its application in the structural elucidation of natural compounds. In the selective separation of diterpenoid-like compounds from the natural plants, ^1H NMR was performed in time after each step of the separation. Combining with the knowledge about the spectral characteristics of the target compounds, the information obtained from ^1H NMR spectra was well used to handle the separation work.

关 键 词：核磁共振(NMR) 选择性分离 结构解析 天然产物 

分 类 号：O482.53[理学—固体物理]