溴莫普林体内抗菌作用的研究  

Study on the in vivo antimicrobial activity of brodimoprim

作　　者：王琪[1] 许军[1] 李家泰[1] 

机构地区：[1]北京医科大学临床药理研究所

出　　处：《中国抗生素杂志》1998年第4期303-305,共3页Chinese Journal of Antibiotics

摘　　要：本文报道溴莫普林与甲氧苄啶的体内抗菌作用比较结果。抗金葡球菌、化脓性链球菌、大肠埃希氏菌、奇异变形杆菌感染小鼠的体内保护试验结果显示：溴莫普林体内抗菌作用明显优于甲氧苄啶，为后者的２．７～６．１６倍。In this paper, we reported the results of in vivo antimicrobial activity of brodimoprim compared with trimethoprim. Results showed that brodimoprim was 2.7-6.16 times more protent than trimethoprim when in mouse protection test against S.aureus, S.pyogenes, E.coli and P.mirabilis. Especially brodimoprim had evidently antimicrobial activities in vivo against S.aureus and P.mirabilis more protent than trimethoprim.

关 键 词：溴莫普林 甲氧苄啶 半数保护剂量 

分 类 号：R978.5[医药卫生—药品]