基因工程产物生技霉素对小鼠致畸作用的研究  

Study on teratogenicity in mice of Shengjimycin,a product of gene recombinaton

作　　者：赵春燕[1] 孙涛[1] 林赴田[1] 王以光[1] 金文藻[1] 

机构地区：[1]中国医学科学院中国协和医科大学医药生物技术研究所

出　　处：《中国抗生素杂志》1998年第4期306-308,318,共4页Chinese Journal of Antibiotics

摘　　要：利用基因重组技术获得的生技霉素对胚胎影响的研究结果表明，生技霉素经口服给药的三个剂量组和阳性对照环磷酰胺组小鼠孕鼠体重均未受明显影响，但环磷酰胺组吸收胎率和死胎率明显增加，活胎率减少，环磷酰胺对胎鼠有明显致畸作用（Ｐ＜０．００１）。生技霉素大剂量对胚胎有一定毒性，所致吸收胎比阴性对照有所增加。Shengjimycin is a product of gene recombination technology. The study of its effect on mice embryo indicated that, after oral administraion of shengjimycin in doses of 0, 10, 200 and 1000 mg/kg body weight (10 mg/kg cyclophosphamidum used as the positive control given intraperitoneally), there was no significant influence on the body weights in all the animal groups. But cyclophosphamidum could induce significant increases of resorptions and mortuary embryos. It also decreased the number of viable embryos and deformed embryos significantly (P<0.001). Shengjimycin in dose of 1000 mg/kg had some toxicity to embryos. The number of resorpted embryos in this group was more than the negative control. But there was no signficant deforming effect on mice embryo in any doses.

关 键 词：生技霉素 环磷酰胺 致畸作用 基因重组 

分 类 号：R978.19[医药卫生—药品] R965.3[医药卫生—药学]