杏仁核微量注射谷氨酸和海人酸对大鼠睡眠—觉醒的影响  

Effects of microinjection of L-glutamate and kainic acidinto nucleus amygdalae on sleep and wakefulness

作　　者：朱国庆[1,2] 赵乐章[1,2] 钟明奎 王敏[1,2] 柯道平 张景行[1,2] 施蕾[1,2] 

机构地区：[1]安徽医科大学生理教研室 [2]安徽中医学院生理教研室

出　　处：《安徽医科大学学报》1998年第4期253-254,共2页Acta Universitatis Medicinalis Anhui

基　　金：安徽省自然科学基金

摘　　要：目的研究杏仁核在睡眠—觉醒调节中的作用。方法多导睡眠描记术（ＰＳＧ）和杏仁核微量注射。结果Ｌ－谷氨酸引起觉醒（Ｗ）增多、慢波睡眠（ＳＷＳ）和总睡眠时间（ＴＳＴ）减少；注射海人酸后第１天引起失眠，第３天后Ｗ减少，ＳＷＳ和ＴＳＴ增多，而快波睡眠无显著变化。结论兴奋杏仁核神经元胞体可引起睡眠抑制，而损毁杏仁核神经元胞体则引起ＳＷＳ增多。Objective To investigate the role of nucleus amygdalae in regulating sleep and wakefulness. Method Polysomnography(PSG) and nucleus amygdalae microinjection. Results L-glutamate(L-Glu) enhanced wakefulness(W), but decreased slow wave sleep(SWS) and total sleep time(TST). Bilateral injection of kainic acid(KA) resulted in biphasic effects. At the first day after KA, insomnia occured. However, SWS and TST increased and W decreased since the third day, but PS did not change significantly. Conclusions The excitation of the cell bodies of neurons in nucleus amygdalae induces a SWSinhibiting effects, but the destruction of nucleus amygadalae increases SWS.

关 键 词：杏仁核 谷氨酸 睡眠 沉醒 海人酸 大鼠 

分 类 号：R338.63[医药卫生—人体生理学] R977.4[医药卫生—基础医学]