L-硝基-精氨酸甲酯对脑创伤后大鼠的神经行为损害  

L-Nitro-arginine -methyl ester does damage to rat neural behaviorafter brain trauma

作　　者：钱洪松[1] 张光霁[1] 朱诚[1] 

机构地区：[1]第二军医大学长征医院神经外科

出　　处：《第二军医大学学报》1998年第4期340-342,共3页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金

摘　　要：目的：探讨一氧化氮合酶（ＮＯＳ）抑制剂对大鼠液压脑损伤后神经行为的影响。方法：大鼠在液压脑创伤后给予不同剂量的Ｌ－硝基－精氨酸甲酯（Ｌ－ＮＡＭＥ）和Ｌ－精氨酸后，检测脑组织中ＮＯＳ的活性，并观察大鼠神经行为的变化。结果：Ｌ－ＮＡＭＥ（８ｍｇ／ｋｇ）延迟神经行为的恢复，Ｌ－ＮＡＭＥ（４０ｍｇ／ｋｇ）可明显抑制ＮＯＳ活性、降低皮质血流量，加重神经行为的损害。Objective: To investigate the effect of nitric oxide synthase inhibitors L-nitro-arginine-methyl- ester (L-NAME) on the neural behavior deficit of rats after fluid percussion brain injury. Methods: The rats neural behavior deficit was observed after various doses of L-NAME and L-arginine (300 mg/kg) were given to rats following fluid percussion brain injury. The activity of nitric oxide synthase was also assayed. Results: L-Arginine did not alter the neural behavior deficit. L-NAME (8 mg/kg) delayed the recovery of rat neural behavior, L-NAME (40 mg/kg) significantly inhibited the activity of nitric oxide synthase and did damage to rat neural behavior compared to the control group. Conclusion: Nitric oxide synthase plays an important role in rat secondary injuries following fluid percussion brain trauma.

关 键 词：神经行为 颅脑损伤 L-NAME 一氧化氮合酶 

分 类 号：R651.150.2[医药卫生—外科学]