结核与艾滋病感染相互影响的研究  

STUDY OF THE INTERACTIVE EFFECT OF TUBERCULOSIS AND AIDS

作　　者：李文俊[1] 李晓灵[1] 蔡琳[1] 辛隽[1] 

机构地区：[1]成都市传染病医院,成都610061

出　　处：《现代预防医学》2009年第17期3358-3359,共2页Modern Preventive Medicine

摘　　要：[目的]探讨艾滋病合并结核病患者与T淋巴细胞之间的关系。[方法]对2005年6月～2008年9月住院的62例艾滋病合并结核病患者与同期住院的艾滋病患者146例及结核病患者118例之间的T淋巴细胞数进行比较分析。[结果]艾滋病合并结核病组、艾滋病组与结核病组比较,CD4+细胞计数之间的差异有统计学意义(P﹤0.01),而艾滋病合并结核病组与艾滋病组比较,CD4+细胞计数之间的差异无统计学意义(P﹥0.05)。当CD4+细胞计数﹤350/mm3时,艾滋病合并结核病的发生率为88.71%,当CD4+细胞计数﹥350/mm3时,艾滋病合并结核病的发生率为11.29%。两组比较差异有统计学意义(P﹤0.01)。[结论]艾滋病合并结核病患者T淋巴细胞数明显下降,免疫功能严重受损,与结核病比较差异显著,但与艾滋病比较则无明显差别。同时,不同水平的CD4+细胞计数,合并结核病感染的几率不同,两者有着密切的关系。因而T淋巴细胞尤其是CD4+细胞计数可作为艾滋病患者开展机会性感染预防的重要参考指标。[ Objective] To explore the change of T-lymphocytes in relation with AIDS complicated with tuberculosis. [ Methods] By comparing and analyzing to the number of T-lymphocytes of 62 cases of AIDS complicated with tuberculosis, 146 cases of AIDS and 118 cases of tuberculosis with the same period, during Jun. 2005 to Sept. 2008. [Results~ There were significant differences in CD4＋ cell count between AIDS with tuberculosis, and AIDS than tuberculosis. CD4＋ cell count had no significant difference between the AIDS with tuberculosis and AIDS. When CD4＋ cell count was less than 350/mm3, incidence of AIDS complicated with tuberculosis was 88.71%, when CD4＋ cell count was more than 350/mm3, and the incidence was 11.29%. There was a significant difference between the two groups. [Conclusion] Number of T-lymphoeytes is decreased sig- nificantly in AIDS complicated with tuberculosis, the immune functions of AIDS complicated with tuberculosis are severe de- stroyed. While, the different level CD4＋ cell counting leads to the different prubability of tuberculosis infection, there is a close relationship. Thus T-lymphocytes, especially CD4＋ cell counts can be used as of important reference index of developing oppor- tunistic infection prevention for AIDS patients.

关 键 词：艾滋病 结核 T淋巴细孢 免疫功能 

分 类 号：R52[医药卫生—内科学] R512.91[医药卫生—临床医学]