β-族溶血性链球菌感染与胎膜早破及母儿预后  

The relation between beta-hemolytic streptococci (GBS) and premature rupture of membranes and influence in the health of pregnant women & their newborns.

作　　者：翁秀琴[1] 秦洁[1] 丁香翠[1] 陈利琼[1] 陈翔[1] 李克诚[1] 

机构地区：[1]温州医学院附属三院妇产科,浙江325200

出　　处：《中国优生与遗传杂志》2009年第9期68-69,共2页Chinese Journal of Birth Health & Heredity

基　　金：温州科技局立项科题(编号Y20080225)

摘　　要：目的探讨β-族溶血性链球菌(GBS)感染与胎膜早破的关系及母儿预后的影响。方法选择胎膜早破(PROM)292例和200例正常妊娠作对照,取宫颈-阴道分泌物进行GBS培养,对GBS阳性的胎膜早破孕妇的羊水作白介素-6测定,并随机选择20例GBS阴性的胎膜早破孕妇作比较,并比较母儿预后。结果胎膜早破孕妇宫颈-阴道分泌物GBS阳性率(14%)明显高于正常组(6.0%)(P<0.05),未足月胎膜早破孕妇122例GBS阳性率(17.2%)明显高于足月胎膜早破孕妇170例(11.8%)(P<0.05),GBS阳性的胎膜早破孕妇羊水白介素-6(IL-6)176.6±82.4ng/L明显高于GBS阴性的胎膜早破孕妇的122.7±59.3ng/L(P<0.05),GBS阳性胎膜早破孕妇的分娩距破膜时间<24h、胎儿窘迫、低体重儿的发生率较阴性孕妇高(P<0.05),产褥感染、新生儿感染发生率较阴性孕妇高,但无统计学意义。结论GBS感染可引起胎膜早破的发生及影响母儿预后。Objective： To explore the relation between beta- hemolytic streptococci （GBS） and premature rupture of membranes （ PROM ） and influence in the health of pregnant women and their newborns. Methods ： The cervical and vaginal secretion samples of premature rupture of membranes （PROM） women （ study group, 292 cases）, and without PROM women （control group, 200 eases） were tested for GBS examination. Then the amniotic fluid was taken from GBS - positive PROM women and 20 cases of GBS - negative PROM women for examination of IL - 6. Results ： The GBS infection rates in study group （ 14% ） were significantly higher than those in control group （6.0%）, and the GBS infection rates in Preterm PROM （ 17. 2% ） were significantly higher than those in Full - term PROM （ 11.8% ） （ P 〈 0. 05）, and IL - 6 in GBS - positive PROM women were added 176. 6 ± 82. 4ng/L than those in GBS- negative PROM women122. 7± 59.3ng/L （ P 〈 0. 05 ）, GBS positive premature rupture membranes women whose incidences of time of less than twenty - four hours from rupture membrane to labor and fetaldistress, low birth weight were all higher than those in the GBS - negative women （ P 〈 0.05 ）, It was also found that there were more puerperal infection, neonatal infection in GBS - positive women than in the GBS -negative women, however nostatistically significant difference. Conclusions： GBS infection can cause the occurrence of premature rupture of membranes （PROM） and GBS is severe enough to threat the health of pregnant women and their newborns.

关 键 词：胎膜早破 β-族溶血性链球菌 白介素-6 

分 类 号：R714.433[医药卫生—妇产科学]