随机尿白蛋白/肌酐比在早期糖尿病肾损害中的临床应用评价  

Clinical evaluate application of albumin to creatinine ratio in early diabetic nephropathy

作　　者：吕艳[1] 王路长[1] 夏汝杰[1] 

机构地区：[1]成都市第二人民医院,610000

出　　处：《中国医学创新》2009年第25期145-146,共2页Medical Innovation of China

摘　　要：目的评价随机尿白蛋白/肌酐检测与24 h尿蛋白定量是否能等效。方法选取确诊糖尿病患者110例和健康对照50例,对其随机尿P/C与24 h尿蛋白定量进行相关分析;比较糖尿病组和正常对照组中微量白蛋白尿和蛋白尿的阳性率。结果糖尿病患者的白蛋白肌酐比的增加与滤过功能下降有关,不同肾功能分期中,随机尿UmAlb/UCr与24h Up定量保持良好的相关性,整体的相关系数0.96。但与24h UmAlb定量相比,随机尿UmAlb/UCr有一定的假阳性。结论尿蛋白检测的影响因素较多,随机尿UmAlb/UCr作为筛查实验有明显的优势,但确诊仍以24h Up定量为佳。Objective To observe could UmAlb/UCr in random urine specimem were equivalent for urinary protein excretion in 24 hours urine specimem in early diabetic nephropathy. Methods 24 h urine collection and random urine specimen were colletted from 110 diabetic patients and 50 health control. The correlion between UmAlb/UCr in random urine specimere and 24 h Up （urine protein）were analyzed the correlations between UmAlb/UCr in random urine specimens and urinary protein excretion in 24 hours collections were analyzed. To compare the positive ratio in diabet group and control group. Resuits The value of UmAlb/UCr in random urine has negative correlations with GFR, while UmAlb/UCr in random urine specimem and 24 h Up keep quite well positive correlations. Compared with 24 h Up, UmAlb/UCr in random urine has some false positive. Conclusion UmAIb/UCr in random urine has certain advantage for scanning nephritic damage, but 24 h Up is better for diagnosis of nephropathy.

关 键 词：随机尿白蛋白/肌酐比 糖尿病肾损害 临床评价 

分 类 号：R587.2[医药卫生—内分泌] R446.12[医药卫生—内科学]