变应性鼻炎患儿血清中IL-25和IL-12的表达与IgE的相关性  

Relation of expression and significance of IL-25,IL-12 and IgE in children with allergic rhinitis

作　　者：姚俊[1] 周慧[1] 许梅[2] 

机构地区：[1]广东医学院附属医院耳鼻咽喉头颈外科,广东湛江524001 [2]广东医学院临床技能培训中心,广东湛江524001

出　　处：《中国耳鼻咽喉头颈外科》2009年第8期447-450,共4页Chinese Archives of Otolaryngology-Head and Neck Surgery

摘　　要：目的探讨变应性鼻炎患儿血清中白细胞介素25(interleukin-25,IL-25)和白细胞介素12(interleukin-12,IL-12)的表达及与IgE的相关性。方法采用酶联免疫吸附法检测34例变应性鼻炎(allergic rhinitis,AR)患儿和34例健康志愿儿血清中IL-25、IL-12和IgE的含量,并进行比较及相关分析。结果间歇性AR组血清IL-25水平为(42.64.±11.77)ng/L,IL-12水平为(38.52±8.32)ng/L,IgE水平为(563.2±141.7)kU/L;持续性AR组血清IL-25水平为(57.51±5.36)ng/L,IL-12水平为(29.31±11.69)ng/L,IgE水平为(625.6±104.3)kU/L;正常对照组血清IL-25水平为(33.42±9.78)ng/L,IL-12水平为(49.31±11.69)ng/L,IgE水平为(209.7±113.2)kU/L。各组间两两比较,间歇性AR组与持续性AR组、间歇性AR组与对照组、持续性AR组与对照组之间差异均具有统计学意义(P<0.05);AR患儿血清IL-25水平与IL-12水平呈显著负相关(r=-0.453,P<0.01);间歇性AR组与持续性AR组血清IgE水平均与对照组IL-25浓度呈正相关,与IL-12浓度呈负相关,相关系数r分别为0.734和-0.661(P均<0.01)。结论IL-25、IL-12与IgE在AR发病机制中均有重要作用,增强IL-12的活性可为AR治疗提供新的靶点与理论依据。OBJECTIVE To investigate the relation of expression and significance of IL-25, IL-12 and IgE in children with allergic rhinitis. METHODS The concentration of IL-25, IL-12 were measured in 34 children with allergic rhinitis and 34 health control subjects by enzyme-linked immunosorbent assay （ELISA） , and compare to them and relationship. RESULTS The concentrations of IL-25, IL-12, IgE in periodicitical allergic rhinitis （AR） were （42.64± 11.77） ng/L, （38.52±8.32） ng/L, （563.2±141.7） kU/L, respectively. And in persistence AR they are （57.51±5.36） ng/L, IL-12 （29.31±11.69） ng/L, （625.6±104.3） kU/L. However, in control group, the concentrations of IL-25, IL-12 and IgE were （33.42 ±9.78） ng/L, （149.31±11.69） ng/L （209.7±113.2） kU/L, respectively. There were significant difference in periodicitical AR and persistence AR, periodicitical AR and control group, persistence AR and control group （P〈0.05~） . The level of IL-25 and IgE were positive correlation between AR and control group. The level of IL-12 were negative correlation between AR and control groups （P〈0.01） . CONCLUSION The expressions of IL-25, IL-12 and IgE have an important role in children with allergic rhinitis. Enhance the activity of IL-12 for the treatment of allergic rhinitis provide a new target with the theoretical basis.

关 键 词：鼻炎 变应性 常年性 白细胞介素类 白细胞介素12 

分 类 号：R765[医药卫生—耳鼻咽喉科]