分泌性白细胞蛋白酶抑制因子在创伤愈合中的潜在应用前景  

Potential application of secretory leukocyte protease inhibitor in wound healing

作　　者：屈纪富[1] 江德鹏[2] 

机构地区：[1]第三军医大学西南医院急救部,重庆400038 [2]重庆医科大学附属第二医院呼吸科,重庆400010

出　　处：《创伤外科杂志》2009年第5期471-473,共3页Journal of Traumatic Surgery

基　　金：国家自然科学基金项目(30370562);国家重点基础研究发展规划(973)项目(G1999054205;2005CB522605)

摘　　要：分泌性白细胞蛋白酶抑制因子(SLPI)是一种可以对抗各种丝氨酸蛋白酶活性的12kDa阳离子蛋白,其羧基末端具有抑制糜蛋白酶、胰弹性蛋白酶等方面的活性,氨基末端有抗细菌、抗真菌、抗逆转录病毒等多方面的活性。近来研究发现,SLPI可通过生长增殖、细胞凋亡、组织改建等多种途径来调控创伤微环境,从而影响创伤愈合进程。本文就SLPI参与创伤愈合过程的可能环节和作用综述如下。Secretory leukocyte protease inhibitor（ SLPI）is a 12-kDa mucosal secretory protein that is identified as a potent inhibitor of various serine proteases. The active inhibitory sites for leukocyte proteases and elastase are located in C-terminal domain ,whereas ,the activities of antibacterial, antifungal and antiretrovirus are found in Nterminal domain. Recent studies suggest that SLPI modulates wound healing via the activities of proliferation, apoptosis,tissue remodelling. This review focuses on the possible approaches and functions of SLPI in the process of wound healing.

关 键 词：分泌性白细胞蛋白酶抑制因子 创伤愈合 增殖 

分 类 号：R392.12[医药卫生—免疫学] R64[医药卫生—基础医学]