单剂量静滴头孢吡肟在中国朝鲜族和汉族健康志愿者的药动学  

Pharmacokinetics of cefepime injection after a single dose in Chinese healthy Korean and Han volunteers

作　　者：杨长青[1,2] 段威[3] 夏东亚[3] 郭涛[3] 郑艳[2] 

机构地区：[1]延边大学附属医院药剂科,吉林延吉133000 [2]延边大学药学院,吉林延吉133000 [3]沈阳军区总医院药剂科,辽宁沈阳110016

出　　处：《中国医院药学杂志》2009年第17期1429-1431,共3页Chinese Journal of Hospital Pharmacy

基　　金：全军医学科学技术研究“十一五”计划科技攻关课题基金资助项目(编号:06G023)

摘　　要：目的:研究朝鲜族健康志愿者单次静脉滴注盐酸头孢吡肟后的药动学,并与汉族志愿者体内药动学进行比较。方法:健康朝鲜族和汉族志愿者各10名,男女各半,单次静脉滴注盐酸头孢吡肟1.0g,定时采血,用高效液相色谱法测定头孢吡肟的血药浓度,用DAS2.0软件进行数据处理,用SPSS11.5软件进行统计分析。结果:朝鲜族和汉族健康志愿者体内头孢吡肟的主要药动学参数分别为:Cmax为(73.8±9.6)、(68.8±10.4)mg·L-1;t1/2β为(2.4±0.6)、(1.97±0.20)h;AUC0-10.5为(139.6±28.7)、(136.9±23.0)mg.h.L-1;AUC0-∞为(142.1±29.8)、(139.7±23.8)mg.h.L-1。结论:朝鲜、汉两民族的种族差异对头孢吡肟的药动学无影响。OBJECTIVE To investigate the pharmacokinetics of cefepime after a single intravenous administration in Chinese healthy Korean and Han volunteers. METItODS Ten Chinese healthy Korean volunteers and ten Chinese healthy Han volunteers were involved in the study. Each subject received a single dose of 1.0 g cefepime hydrochloride. The plasma concentration was determined by HPLC. The pharmacokinetics parameters were calculated by DAS 2. 0 software and were compared by SPSS 11.5 software. RESULTS The main pharmacokinetics parameters of cefepime in Chinese Korean and Chinese Han volunteers were as follows.. Cmax were（73.8±9.6）、（68.8±10.4）mg·L;t1/2β were（2.4±0.6）、（1.97±0.20）h;AUC0-10.5were（139.6±28.7）、（136.9±23.0）mg·h·L^-1;AUC0-∞were（142.1±29.8）、（139.7±23.8）mg·h·L^-1. CONCLUSION The ethnic difference between Chinese Korea and Han did not influence on the pharmacokinetics of cefepime.

关 键 词：头孢吡肟 高效液相色谱法 药动学 朝鲜族 汉族 

分 类 号：R969[医药卫生—药理学]