血吸虫基因操作研究进展  

Advances in genetic manipulations of schistosomes

作　　者：陈晶[1] 林矫矫[1] 蔡幼民[1] 程国锋[1] 

机构地区：[1]中国农业科学院上海兽医研究所,农业部动物寄生虫学重点开放实验室,上海200241

出　　处：《生命科学》2009年第4期579-583,共5页Chinese Bulletin of Life Sciences

基　　金：国家重点基础研究发展计划"973"项目(2007CB513108)

摘　　要：近年来,血吸虫基因组、转录组、蛋白质组和分泌组研究广泛开展,迫切需要针对单个分子功能深入研究。开展血吸虫基因操作研究不仅可在虫体内深入研究基因功能,对进一步理解血吸虫生长发育机理和寄生生活特征具有重要意义,还可建立抗血吸虫候选疫苗和药物靶标筛选的重要平台。为此,本文总结基因操作技术在血吸虫学中的应用并分析其现状。There is a great need for deeply understanding the functions of single molecule of schistosomes in vivo due to the accumulated information from schistosome genomics, transcriptomics and proteomics. The studies on genetic manipulations of schistosomes not only provide the techniques for further investigating gene functions of schistosomes in vivo, which could help not only to understand the mechanism of schistosome growth and development as well as parasitic characters, but also establish the platform for screening novel vaccine candidates and/or drug targets for controlling schistosomiasis. Therefore, we reviewed the advances in genetic manipulations of schistosomes, its application, and its current status.

关 键 词：血吸虫 基因操作 疫苗 药物靶标 

分 类 号：S85[农业科学—兽医学] R18[农业科学—畜牧兽医]