胞嘧啶核苷键联卟啉的合成及其与牛血清白蛋白的相互作用  

Synthesis of Cytidine-bonded Porphyrins and Their Interaction with Bovine Serum Albumin

作　　者：江国防[1] 高峰[1] 张满生[2] 刘畅[1] 郭灿城[1] 

机构地区：[1]化学生物传感与计量学国家重点实验室,湖南大学化学化工学院,长沙410082 [2]湖南公安高等专科学校,长沙410138

出　　处：《高等学校化学学报》2009年第9期1724-1728,共5页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20502005);湖南省重点科技项目(批准号:2008GK2023);湖南大学重点基金(批准号:521101787)资助

摘　　要：基于卟啉化合物的光敏性和对肿瘤细胞有特殊的亲和力以及核苷类化合物的抗肿瘤及抗癌活性,设计合成了胞嘧啶核苷卟啉化合物6和8,其结构由1HNMR,IR,UV-Vis,MS和元素分析表征.同时,利用荧光光谱考察了上述核苷卟啉与牛血清白蛋白(BSA)的相互作用,结果表明它们对BSA荧光有较强的静态猝灭作用.Cytidine-bonded porphyrins 6 and 8 were designed and synthesized on the basis of porphyrin＇s photosensitivity, special affinity for tumor cells, nucleosides＇ antitumor and antieancer activities. Molecular structures of all synthesized compounds were characterized by 1H NMR, IR, UV-Vis, MS and elemental analysis. The interaction between cytidine-bonded porphyrins 6, 8 and bovine serum albumin （BSA） was investigated by fluorescence spectrum. The results show that the novel cytidine-bonded porphyrins 6 and 8 own a powerful ability of quenching the fluorescence of BSA via static quenching.

关 键 词：胞嘧啶 卟啉 牛血清白蛋白 荧光光谱 

分 类 号：O621.3[理学—有机化学] O657[理学—化学]