稀土、钼酸、糠醛缩水杨酰肼三元配合物的合成、表征及生物活性的研究  

Synthesis, Characterization and Biological Activity of Rare Earth Complexes with Fural Salicylhydrazone and Molybdic Acid

作　　者：夏庆春[1] 沈智慧[1] 何其庄[1] 许东芳[1] 彭子飞[1] 邵超英[2] 

机构地区：[1]上海师范大学生命与环境科学学院,上海200234 [2]东华大学化学化工与生物工程学院,上海201620

出　　处：《化学学报》2009年第16期1843-1850,共8页Acta Chimica Sinica

基　　金：国家自然科学基金(No20671063);上海市稀土功能材料重点实验室(No07dz22303);上海市重点学科建设(NoS30406);上海师范大学重点学科(NoDZL711)资助项目

摘　　要：通过回流冷凝法和低温固相法制备了8种稀土、钼酸、糠醛缩水杨酰肼三元配合物,并通过元素分析,摩尔电导,IR,UV-vis,TG-DTA,TC-ICP,XRD,XPS对其结构和化学组成进行表征,确定其化学组成为Re(HL)MoO4Cl?6H2O(HL:糠醛缩水杨酰肼),通过抑菌实验表明所制备的三元化合物对大肠杆菌和金黄色葡萄球菌具有中等抑制作用,属于广谱抗菌剂;通过MTT比色法对配合物使癌细胞凋亡能力做了初步研究,结果表明,三元配合物的IC50在10～100ng/mL之间,对癌细胞具有较强的抑制杀伤作用,具有潜在的药物应用价值.Using a reflux condensation method and a low-temperature solid phase method, eight kinds of new ternary complexes were synthesized with rare earth chloride, molybdenum acid and rural salicylhydrazone. Their compositions were characterized by elemental analysis, molar conductance, FT-IR, UV-vis, TG-DTA, TC-ICP, XRD and XPS, and confirmed to be Re（HL）MoO4Clo6H20 （HL： rural salicylhydrazone）. The antibacterial activity testing shows that all the complexes exhibit antibacterial ability against Es- cherichia coli and Staphylococcus aureus. The antimicrobial spectrum of the complexes is broad. MTT was used to study the anticancer ability of the complexes, which indicates that the cancer cells were killed by the complexes. All the complexes have potential drug application.

关 键 词：配合物 抑菌 抗肿瘤 

分 类 号：O627[理学—有机化学]