氯磷定持续静脉泵入治疗急性有机磷农药中毒51例分析  

Therapy with continous intravenous infusim pralidoxime chloride therapy in acute organophosphorus pesticide poisoning

作　　者：金先银[1] 何军[1] 王建斌[1] 

机构地区：[1]淮北市人民医院急诊科,安徽省淮北235000

出　　处：《中国基层医药》2009年第8期1385-1386,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨持续静脉泵入氯磷定治疗急性有机磷中毒（AOPP）的疗效。方法将符合重症有机磷中毒患者分为三组：一组：静脉注射氯磷定2．0g，后以0．25g／h静脉泵人；二组：静脉注射氯磷定2．0g，后以0．5g／h静脉泵人；三组：氯磷定每次2．0g，每天3次静脉滴入。观察各组疗效与并发症。结果一组与二组比较，在加快阿托品化，减少阿托品用量，恢复胆碱酯酶活力，缩短住院天数，减少反跳数和中间综合征的发生，提高治愈率方面差异无统计学意义，但两组与第三组比较有明显差异。结论氯磷定首剂足量，继以小剂量静脉维持泵人对治疗AOPP效果更好。Objective To investigate the therapeutic effect of continuous intravenous pralidoxime chloride infusion in acute organophosphorus pesticide poisoning（AOPP）. Methods The patients with severe AOPP were randomly divided into 3 groups ： （ 1 ） group 1 （ n = 51 ） received a bolus injection of pralidoxime chloride 2.0g followed by continuous intravenous infusion at 0. 25 g/h. （2） group 2 （ n = 51 ） received a bolus injection of pralidoxime 2. 0g followed by continuous intravenous infusion at 0. 5g/h. （3） group 3 （ n = 50） received intravenous drip of pralidoxime 2. 0g for 3 times a day. Efficacy was compared among 3 groups on the basis of time to reach atropinization, recovery of cholinesterase activity, cumulative amount of atropine, incidence of recurrence of pesticide poisoning, intermediate syndrome, and hospitalization days, etc. Results Efficacy in patients receiving Continuous intravenous therapy was significantly different from the third group. But there was no significant difference in efficacy between the first and second groups. Conclusion The patients with AOPP can be effectively treated by a loading dose followed with continous intravenous pralidoxime chloride infusion.

关 键 词：氯磷定 持续静脉输注 有机磷农药 中毒 

分 类 号：R5[医药卫生—内科学]