口腔颌面部淀粉样变性病的临床病理研究  

Clinicopathological and diagnostic study of amyloidosis of oral maxillofacial area

作　　者：周志瑜[1] 卢勇[1] 吴兰雁[1] 杨名仲[1] 

机构地区：[1]华西医科大学口腔医学院

出　　处：《中华口腔医学杂志》1998年第5期282-284,共3页Chinese Journal of Stomatology

摘　　要：目的探讨全身系统性淀粉样变性病在口腔颌面部的临床病理特点。方法对１４例口腔颌面部淀粉样变性病的活检切片ＨＥ及刚果红等特殊染色、免疫组化、光镜和偏光显微镜超微结构观察。结果１４例的活体组织检查发现肿物为软组织和血管壁有粉红均质的淀粉样蛋白沉积，刚果红等特殊染色阳性，结合免疫组织化学染色可鉴别原发和继发性病，透射电镜观察淀粉样蛋白呈毛毡样的细丝状物。结论淀粉样变性病在口腔主要损害舌。Objective to study the clinicopathological features of amyloidosis studied in oral maxillofacial area and the diagnostic methods. Methods HE staining and staining of alkaline Congo red, Immunohistochemical staining, Sections examined by transmitted and polarized light microscopy, Transmitted electron microscopy. Results 14 cases of the disease were reported. Clinically, the patients usually had progressive enlargement and solidness of the tongue (macroglossia, 12 cases), hard nodules or cords of the cheek and lip mucosa (8 cases), single or multiple hard masses of submandibular and submental areas (6 cases), and ecchymosis or petechiae of the face, neck, chest or oral mucosa. Microscopically, the disease is characterized by the even pink amyloid protein deposit in the soft tissues and the wall of blood vessles, which shows positive staining of alkaline Congo red, Immunohistochemical staining can differentiate the primary amyloidosis from secondary one. Ultrastructurally, Amyloid protein appeares as felt like finely filament. Conclusion amyloidosis involving in oral maxillofacial area mainly arise in tongue, less frequently, in buccal and lip mucosa, salivary glands. It is not difficulty to dignosis the disease by HE staining combining with staining of alkaline Congo red and other specific staining methods. Ultrastructural and immunohistochemical study is helpful to make show the dignosis.

关 键 词：淀粉样变性病 口腔颌面部损害 病理学 

分 类 号：R597.202[医药卫生—内科学]