血小板活化在哮喘发病中的作用  

Effects of platelet activation on broncial asthma

作　　者：孔晓梅[1,2] 杨莉丽[1,2] 窦岩[1,2] 杜永成[1,2] 王予思[1,2] 

机构地区：[1]山西医科大学第一临床医学院呼吸内科 [2]山西医科大学中心实验室

出　　处：《山西医科大学学报》1998年第3期207-208,共2页Journal of Shanxi Medical University

基　　金：山西省教委归国人员科研基金

摘　　要：目的：为了进一步探讨血小板活化和哮喘发病的关系，对哮喘患者血小板膜糖蛋白（ＧＰ）进行测试，并分析其临床意义。方法：用流式细胞仪测定哮喘患者和健康人血小板膜糖蛋白ＧＰⅠｂ１ＧＰⅠｂ／Ⅸ、ＧＰⅡｂ／Ⅲａ、ＧＭＰ－１４０。结果：哮喘组（３６例）与正常对照组（１３例）上述；四项指标均有显著差异（Ｐ＜０．０１）。结论：通过本实验证实了哮喘时有血小板活化现象，ＧＰ可作为血小板活化的分子标志物。不同的ＧＰ通过不同的途径介导了血小板的活化。To study the relationship between asthma and platelet activation,the levels of platelet membrane glycoprotein(GP)in blood from 34 patients with asthma and 14 health subjects were compared. All the indexes were detected by flow cytometry(FCM). Results showed that the levels of GP I b,I b/Ⅸ,Ⅱb/Ⅲa and GMP-140 in blood were significantly higher in patients with asthma than in controls.These support that platelet activetion exists in asthma.In conclusion,GP can act as a molecular sign of platelet activation and takes part in attack of asthma through platelet activation.

关 键 词：哮喘 血小板活化 糖蛋白类 

分 类 号：R562.25[医药卫生—呼吸系统]