维拉帕米对慢性肾衰大鼠T、B细胞的影响  

Effect of Verapamil on T,B Lymphocyte Functions of Rats with CRF

作　　者：左静南[1] 方文军[1] 侯积寿[1] 

机构地区：[1]上海第二医科大学附属新华医院内分泌科,200092

出　　处：《上海第二医科大学学报》1998年第5期370-371,共2页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：采用5/6肾切除的慢性肾功能衰竭(CRF)大鼠模型观察维拉帕米对 CRF 时 T、B 细胞功能的影响。结果发现:CRF 鼠 T、B 细胞功能低下,维拉帕米治疗能促进 CRF 鼠 T 细胞转化和 IL-2生成,提高机体在抗原刺激下的抗体水平。提示:CRF 鼠免疫功能缺陷与钙离子代谢异常有关。The effect of verapamil on T,B lymphocyte functions was observed in rats withchronic renal failure (CRF).Results showed T,B lymphocyte functions of CRF rats were impaired.Verapamil could improve lymphocyte proliferation,IL-2 production by T cell and serum anti-HBSlevel of CRF rats.It suggests that the disorder of calcium metabolism might be related to the impairedimmunity of CRF rats.

关 键 词：肾功能衰竭 T细胞 B细胞 维拉帕米 药物疗法 

分 类 号：R692.505[医药卫生—泌尿科学]