Therapy of central pontine myelinolysis following livingdonor liver transplantation:Report of three cases  

作　　者：Zhong-Wei Zhang Yan Kang Li-Jing Deng Chuan-Xing Luo Yan Zhou Xin-Sheng Xue Dong Wang Wan-Hong Yin 

机构地区：[1]Intensive Care Unit, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China

出　　处：《World Journal of Gastroenterology》2009年第31期3960-3963,共4页世界胃肠病学杂志（英文版）

摘　　要：We analyzed the clinical manifestations and experiences of diagnosing and treating central pontine myelinolysis following living donor liver transplantation. The clinical data of three patients with central pontine myelinolysis following living donor liver transplantation from January 2005 to November 2007 were retrospectively analyzed at the West China Hospital, Sichuan University, China. The three patients developed hyponatremia prior to surgery. Case 1 suffered locked-in syndrome following surgery, and received a large dose of gamma globulin, and subsequently recovered. Case 2 was in a coma for three days, and received hyperbaric chamber treatment. This patient remained in a mild coma for six months following surgery. Case 3 developed consciousness disturbances, gradually went into a coma following surgery, and died due to pulmonary infection. Central pontine myelinolysis is a severe complication in patients following living donor liver transplantation. Large-dose gamma globulin treatment, as well as hyperbaric oxygen, might be effective therapeutic methods.We analyzed the clinical manifestations and experiences of diagnosing and treating central pontine myelinolysis following living donor liver transplantation. The clinical data of three patients with central pontine myelinolysis following living donor liver transplantation from January 2005 to November 2007 were retrospectively analyzed at the West China Hospital, Sichuan University, China. The three patients developed hyponatremia prior to surgery. Case 1 suffered locked-in syndrome following surgery, and received a large dose of gamma globulin, and subsequently recovered. Case 2 was in a coma for three days, and received hyperbaric chamber treatment. This patient remained in a mild coma for six months following surgery. Case 3 developed consciousness disturbances, gradually went into a coma following surgery, and died due to pulmonary infection. Central pontine myelinolysis is a severe complication in patients following living donor liver transplantation. Largedose gamma globulin treatment, as well as hyperbaric oxygen, might be effective therapeutic methods.

关 键 词：CYCLOSPORINE HYPONATREMIA Liver transplantation MYELINOLYSIS PONTINE 

分 类 号：S858.23[农业科学—临床兽医学] TU998.12[农业科学—兽医学]