熊去氧胆酸对胆肠吻合术后胆道逆行性感染的预防作用  

The effect of ursodeoxycholic acid on prevention of retrograde biliary tract infection after cholangioenterostomy

作　　者：孙治国[1] 孙备[1] 王刚[1] 李军[1] 刘杰[1] 姜洪池[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院普通外科,黑龙江哈尔滨150001

出　　处：《中国普通外科杂志》2009年第8期821-823,共3页China Journal of General Surgery

基　　金：教育部新世纪优秀人才支持计划(NCET-07-0248);黑龙江省杰出青年基金资助项目(JC200717)

摘　　要：目的探讨熊去氧胆酸(UDCA)对胆肠吻合术后胆道逆行性感染的预防作用。方法将2年间收治的50例接受胆肠吻合术的患者随机分为对照组和观察组。除传统的胆肠吻合术后处理外,对照组于术后给予维生素C,而观察组则给予UDCA。比较两组术后胆道逆行性感染的发生率。所有患者术后随访6个月至2年。结果观察组术后胆道逆行感染的发生率较对照组显著降低(4.0%vs.32.0%)(P<0.05)。结论胆肠吻合术后应用UDCA安全,可显著降低术后胆道逆行感染的发生率。Objective To investigate the effect of ursodeoxycholic acid （ UDCA ） on prevention of retrograde biliary tract infection after cholangioenterostomy. Methods Fifty patients undergoing cholecystojejunostomy, cholangio-jejunostomy, pancreaticoduodenectomy and choledochoduodenostomy treated in our hospital, during a 2-year period, were randomly divided into control group and observation group, respectively. In addition to conventional postoperative care, control group received vitamin C, while UDCA was given to observation group. The incidence of postoperative retrograde infection of biliary tract in the two groups was compared. The duration of follow-up varied from 6 months to 2 years. Results Compared with control group, The incidence of postoperative retrograde biliary tract infection in therapy group was significantly lower than that in comtrol group （ 4.0% vs. 32.0 % ） （ P 〈 0.05 ）. Conclusions Administration of UDCA following cholangioenterostomy is safe, and it can significantly reduce the occurrence rate of retroarade biliarv tract infection.

关 键 词：熊去氧胆酸 胆道逆行性感染/预防与控制 胆肠吻合术 

分 类 号：R657.4[医药卫生—外科学]