妊娠高血压综合征患者血浆一氧化氮与内皮素-1的变化及其意义  

Changes of Plasma Nitric Oxide and Endothelin-1 Levels in Pregnancy-induced Hypertension Patients

作　　者：王晨虹[1] 萧根秀[1] 郑毓秀 谈海英[1] 赵瑞钦 

机构地区：[1]湖南医科大学附属第二医院

出　　处：《湖南医学》1998年第5期257-259,共3页Hunan Medical Journal

摘　　要：本文应用Ｇｒｉｅｓｓ法及放射免疫法测定６０例妊娠高血压综合征患者、２３例正常晚期妊娠妇女、２２例健康非孕妇女血浆ＮＯ－２／ＮＯ－３和ＥＴ－１水平。结果表明：妊高征患者血浆ＮＯ－２／ＮＯ－３下降，ＥＴ－１上升。两者呈明显负相关。本文结果提示：一氧化氮与妊高征病情呈负相关；ＥＴ－１与妊高征病情呈正相关；ＮＯ和ＥＴ－１在妊高征中呈负相关。ＮＯ／ＥＴ－１比值越小，妊高征病情越重。To investigate the role of nitric oxide(NO) and endothelin(ET-1) in the pathophysiology of pregnancy induced hypertension(PIH),60 patients with PIH and 23 healthy women in their late pregnancy and 22 healthy non-pregnancy women were studied.The antepartum and postpartum plasma NO - 2/NO - 3 levels,the stable metabolic end products of NO,and ET-1 levels were measured with Griess assay and radioimmunoassay respectively.Results showed that:①The levels of plasma NO - 2/NO - 3 in patients with PIH decreased significantly when compared with that of healthy pregnant and non-pregnant women(P<0.01);②The levels of plasma ET-1 in patients with PIH were significantly higher than those in healthy pregnant and non-pregnant women(P<0.01);③There is a negative correlation between NO - 2/NO - 3 and ET-1 in PIH(γ=-0.7268,P<0.01).The results suggest:① a negative correlation between the plasma NO level and degree of PIH;②a positive correlation between the plasma ET-1 level and degree of PIH;and ③ a negative correlation between NO and ET-1 in patients with PIH.The smaller the NO/ET-1 ratio,the severer the PIH.There may exist:①the inhibitor of nitric oxide synthesis(NOS) in the patients with PIH or ②the gene deficiency of NOS in the patients with moderate or severe PIH.

关 键 词：妊娠高血压 综合征 血浆 一氧化氮 内皮素1 

分 类 号：R714.246[医药卫生—妇产科学]