民康胶囊对小鼠睡眠功能影响实验研究  

Studies on the effect of Minkang capsules on sleep function of mice

作　　者：李鸣[1] 刘用国[1] 王江融[1] 谢志萍[1] 

机构地区：[1]福建省药品检验所,福州350001

出　　处：《海峡药学》2009年第8期32-34,共3页Strait Pharmaceutical Journal

摘　　要：目的研究民康胶囊对小鼠睡眠功能的影响。方法给予小鼠连续灌胃给药30天后,分别进行直接睡眠实验、延长戊巴比妥钠睡眠时间实验、戊巴比妥钠阈下剂量催眠实验、巴比妥钠睡眠潜伏期实验。结果民康胶囊对小鼠无直接睡眠作用(P>0.05);0.81g.kg-1剂量组能明显延长戊巴比妥钠对小鼠的睡眠时间(P<0.05)、增加戊巴比妥钠阈下催眠剂量入睡动物数(P<0.05).结论民康胶囊具有改善睡眠功效。OBJECTIVE To study the effect of Minkang capsules on the sleep function of the mice. METHODS The mice were given Minkang capsules through gastric route continually for 30 days. The effect of sleep improvement was studied by the experiments of sleep-induced directly, prolonging sleeping time induced by pentobarbital sodium, affecting mice sleeping rate under the threshold hypnogenesis dosage of pentobarbital sodium and affecting sleeping delitescence induced by tobarbital sodium. RESULTS Minkang capsules had no direct effect on the sleep of the mice （P 〉0.05）; The dosage of 0.81g· kg^-1 could significantly prolong the time of sleep induced by pentobarbital sodium （P 〈 0.05）, and increased the number of sleeping mice induced by subthreshold dose of pentobarbital sodium （P 〈 0.05 ）.CONCLUSION Minkang capsules could improve the sleep function.

关 键 词：民康胶囊 小鼠 睡眠 

分 类 号：R969[医药卫生—药理学]