DTPA-多甘醇-磷酸酯三元共聚物钆(Ⅲ)配合物的合成与表征  

Synthesis and Characterization of Gadoliniun(Ⅲ) Complexes of Phosphate-DTPA-Polyethylene Glycol Terpolymer

作　　者：俞开潮[1,2] 卓仁禧 刘午阳[1,2] 

机构地区：[1]国家教委生物医用高分子材料开放实验室 [2]中国科学院武汉物理与数学研究所波谱与原子分子物理国家重点实验室

出　　处：《合成化学》1998年第2期166-170,共5页Chinese Journal of Synthetic Chemistry

基　　金：波谱与原子分子物理国家重点实验室开放基金

摘　　要：以二亚乙基三胺五乙酸双酐和二氯磷酸酯与多甘醇共缩聚，制得一系列三元共聚物配体及其钆（Ⅲ）配合物。对配体和配合物进行了结构表征，并测试了配合物的弛豫效能。A series of terpolymer ligands and their Gd(Ⅲ) complexes were synthesized by solution polycondensation of diethylene glycol, triethylene glycol, tetraethylene glycol with ethyl phosphodichloridate, methyl phosphodichloridate, nbytyl phosphodichloridate and diethylene triamine pentaacetic dianhydride (DTPAA). The structures of the ligands and their Gd(Ⅲ) complexes formed from the ligiands and Gadolinium(Ⅲ) chloride hexahydrate were characterized by IR and elemental analysis. The longitudinal relaxivity of these Gd(Ⅲ) complexes was preliminarily investigated.

关 键 词：多甘醇 磷酸酯 共聚物 MRI 造影剂 钆 配合物 

分 类 号：TQ462.91[化学工程—制药化工]