壳聚糖澄清剂对牛角地黄颗粒纯化工艺的影响  

Impact of chitosan clarifier on purification technology of Niujiaodihuang granule

作　　者：冯俭[1] 朱晗[1] 李煌[1] 张梦云[1] 张煜华[1] 

机构地区：[1]成都中医药大学附属医院,四川成都610072

出　　处：《Journal of US-China Medical Science》2009年第8期64-67,共4页美中医学（英文版）

摘　　要：目的探讨壳聚糖澄清剂封牛角地黄颗粒纯化工艺的影响。方法比较乙醇沉淀法和壳聚糖澄清剂封牛角地黄颗粒的纯化效果。考察指标为干浸膏得率、芍药苷保留率、多糖保留率。结果乙醇沉淀法和壳聚糖澄清剂纯化牛角地黄颗粒工艺效果相近，均使制剂干浸膏得率明显减少，但乙醇沉淀法使多糖含量显着降低，而壳聚糖封多糖含量影响较小，且芍药苷保留率较高。结论利用壳聚糖澄清剂纯化牛角地黄颗粒除杂质效果较好，制剂质量稳定。Objective To investigate the impact of chitosan clarifier on purification technology of Niujiaodihuang granule. Methods The effects of alcohol sedimentation and chitosan clarifier were measured, and the indexs evaluated were the remaining rates of paeoniflorin and polysaccharide and the rate of dry extra. Results It was showed that the techniques of alcohol sedimentation and chitosan clarifier were similar in the clarify and the stability. Chitosan clarifier had better effects on the remaining rates of paeoniflorin and polysaccharide, compared with alcohol sedimentation. Conclusion Chitosan technology is a better purification and the quality of preparation is stable.

关 键 词：牛角地黄颗粒 壳聚糖澄清剂 乙醇沉淀法 澄清工艺 

分 类 号：R283[医药卫生—中药学] R284.2[医药卫生—中医学]