血小板输注有效剂量的临床应用研究  

The effective dose for platelet transfusion

作　　者：傅佳萍[1] 周国忠[1] 冯水堂[1] 葛国兴[1] 狄黎明[1] 

机构地区：[1]绍兴市人民医院血液科,312000

出　　处：《浙江医学》2009年第7期910-912,共3页Zhejiang Medical Journal

摘　　要：目的探讨血小板输注的有效剂量和影响血小板输注有效率的相关因素。方法观察124例血液病患者输血后血小板增加的校正值（CCl）、出血情况及输血间隔的变化，并对多次输血、脾肿大等影响血小板输注疗效的相关因素进行分析。结果血小板输注量和血小板输注有效率呈正相关，以0.15～0．2U／Kg为宜，同时输注间隔亦明显延长；血小板输注次数和输注有效率呈负相关；轻度脾肿大不影响输注疗效。结论血小板输注的有效剂量以0.15～0.2U／Kg为宜，且血小板输注量和输注次数与有效率相关。Objective To investigate the effective dose and related factors in platelet transfusion. Methods The study involved 124 patients who received transfusion, the modified platelet corrected count increase （CCI） was calculated; the transfusion interval and bleeding symptoms were observed. The influencing factors, including repeated transfusion and spleen enlargement were analyzed. Results Effective rate of platelet transfusion was positively correlated with transfusion dose. With the appropriate dose of 0.15-0.2U platelets/kg the transfusion interval can be prolonged. Effective rate of platelet transfusion was negatively correlated with transfusion times. Mild spleen enlargement did not affect transfusion efficacy. Conclusion Effective transfusion rate in platelet transfusion correlated with transfusion dose and times.

关 键 词：血小板 输注 有效剂量 

分 类 号：R457.1[医药卫生—治疗学] R971.1[医药卫生—临床医学]