CRP+1444C/T多态性与2型糖尿病的关系  

Association between +1444C/T polymorphism in C-reactive protein (CRP) gene and type 2 diabetes mellitus

作　　者：石峻[1] 刘志忠[2] 丁秀荣[1] 殷华[1] 夏静[1] 康熙雄[2] 

机构地区：[1]华北煤炭医学院附属医院,河北唐山063000 [2]首都医科大学附属北京天坛医院

出　　处：《山东医药》2009年第27期1-3,共3页Shandong Medical Journal

基　　金：国家863计划重点项目(2006AA020706)

摘　　要：目的探讨C反应蛋白(CRP)+1444C/T基因多态性与2型糖尿病(T2DM)的相关性。方法采用PCR-RFLP法对156例T2DM患者(T2DM组)和149例健康体检者(NC组)行+1444C/T基因型检测,同时测定血清CRP水平。结果T2DM组血清CRP水平显著高于对照组;两组均未检测到TT基因型,两组CRP+1444C/T的基因型和等位基因频率分布比较均无统计学差异,对照组CT基因型者CRP水平显著高于CC基因型者。结论CRP+1444C/T基因多态性与T2DM无相关性,血清CRP水平升高与T2DM有关。Objective To investigate the relation between ＋1444C/T polymorphism in C-reactive protein（CRP）gene and type 2 diabetes mellitus（T2DM）.Methods CRP＋1444C/T polymorphism was detected by polymerase chain reaction-restriction fragment-length polymorphism in 156 patients with T2DM（T2DM group）and 149 healthy subjects（NC group）.The level of serum hs-CRP was detected too.Results The level of hs-CRP in T2DM group were significantly higher than that in NC group.No TT genotype was found in two groups.There was no significant difference in the frequency of CRP ＋1444C/T genotype and allele between T2DM and NC groups.The hs-CRP level of individuals with CT genotype in NC group was significantly higher than that with CC genotype.Conclusions The CRP ＋1444C/T polymorphism bears no relation to T2DM.The higher level of serum CRP is associated with T2DM.

关 键 词：糖尿病 2型 C反应蛋白 基因多态性 

分 类 号：R587.1[医药卫生—内分泌]