淋巴毒素α及半乳凝素2与冠心病关联性的研究进展  

Research Progress of the Relationship between Lymphotoxia-α,Galectin-2 and Coronary Artery Disease

作　　者：李文龙[1] 惠汝太 

机构地区：[1]北京协和医学院,中国医学科学院,阜外心血管病医院,教育部心血管病相关基因与临床重点实验室,中德实验室,北京100037

出　　处：《医学综述》2009年第18期2721-2723,共3页Medical Recapitulate

基　　金：国家高技术研究发展计划(2006AA02A406);国家重点基础研究发展计划(2006CB503805)

摘　　要：冠心病是最常见的心脏疾病,也是导致死亡的主要疾病,其病理基础是动脉粥样硬化。淋巴毒素α是重要的前炎性因子,参与趋化因子的释放、细胞之间的黏附和聚集等,在动脉粥样硬化的发生发展中起重要作用。半乳凝素2参与淋巴毒素α的分泌过程,降低其表达水平可能会减弱动脉炎性过程。本文就淋巴毒素α及半乳凝素2与冠心病的关联研究进展予以综述。Coronary artery disease is a most common heart disease and the leading causes of death. Atherosclerosis is the common pathologic basis of coronary artery disease. The inflammation of artery wall plays crucial roles in initiation and development of atherosclerosis. Lymphocoxia-αt is an important proinflammatory cytokine and plays a key role in inducing adhesion molecules and cytokines. Galeetin-2 is expressed in atherosclerotic plaques and involves in the translocation of lymphctoxia-α. Inhibition of galectin- 2 may suppress the inflammatory process of arteries. This article reviewed the relationship between lymphotoxia-α,galectin-2 and coronary artery disease.

关 键 词：淋巴毒素Α 半乳凝素2 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]