血液灌流串联透析与血液透析滤过对尿毒症贫血疗效的对比研究  

Compare the effects of hematopoietin therapy on maintenance hemodialysis patients of anemia with blood perfusion in series with hemodialysis or hemodialysis filtration

作　　者：张英姿[1] 胡宏[1] 刘金洪[1] 

机构地区：[1]江阴市人民医院,江苏江阴214400

出　　处：《西部医学》2009年第9期1494-1496,共3页Medical Journal of West China

摘　　要：目的观察血液灌流串联血液透析(HP+HD)与血液透析滤过(HDF)联合促红细胞生成素(EPO)治疗对维持性血液透析(MHD)患者贫血的疗效。方法选择MHD贫血患者40例,随机均分成HP+HD组与HDF组,HP+HD组在每周2次常规HD的同时,每周行一次HP+HD;HDF组在每周2次常规HD的同时,每周行一次HDF;每次透析时间均为4小时。均接受促红素皮下注射,口服铁剂、叶酸补充造血原料。观察6个月,检测中小分子溶质及贫血指标。结果两组透析后小分子溶质的下降率无明显差异,中大分子溶质(β2-Mg、PTH、炎症因子等)的下降率HP+HD组优于HDF组,血红蛋白、血细胞比容上升HP+HD组亦优于HDF组,差异有显著性(P<0.05)。结论联合红细胞生成素的使用,HP+HD在保证对小分子量毒素充分清除的基础上,增加了对中大分子量毒素的清除,治疗尿毒症贫血较HDF更有效。Objective To compare the effects of hematopoietin therapy on maintenance hemodialysis（MHD）patients of anemia with blood perfusion in series with hemodialysis （HP＋HD）or hemodialysis filtration（HDF）. Method Choose MHD 40 patients, random anemia patients are divided into HP ＋ HD group and HDY group. HP ＋ HD group in weekly 2 times per week HD, regular once did HP ＋HD, HDF group in twice per week, weekly regular HD do a HDF, Each time for 4 hours dialysis. All accept promote red meat subcutaneous injection, oral iron, folic acid supplements hematopoietic materials agent. Observe 6 months, detection of small molecules solute and anemia index. Results Two sets of small molecules solutes after treatment, the decline rate no obvious difference in macromolecular solute β2 Mg, PTH）, inflammation factors in HP ＋D group, hemoglobin is HDF hematocrit value, rising HP ＋ HD group, more than HDF group also has significant difference （P〈0.05）. Conclusion Combined the use of eryt HP ＋ HD, in that small molecules to remove toxin, on the basis of the full weight has increased to remove toxin and cuhk uremia anemia treated more HDF more effective.

关 键 词：血液灌流串联血液透析 血液透析滤过 贫血 疗效对比 

分 类 号：R692.5[医药卫生—泌尿科学]