Efficient synthesis of 5,6-dihydrothieno[3′,2′:4,5]-thieno[2,3-d]pyrimidin-4(3H)-ones via an iminophosphorane  

作　　者：Yu Lu Chen Yi Bo Nie Ming Wu Ding 

机构地区：[1]Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Central China Normal University, Wuhan 430079, China [2]Department of Biology, Xianning Vocational and Technical College, Xianning 437100, China

出　　处：《Chinese Chemical Letters》2009年第9期1055-1058,共4页中国化学快报（英文版）

基　　金：support of this work by the National Natural Science Foundation of China(No.20772041);Key Project of Science and Technology of Ministry of Education of China(No.107082)

摘　　要：5,6-Dihydrothieno[3＇,2＇：4,5]thieno[2,3-d]pyrimidin-4（3H）-ones 6 were synthesized in yields of 71-87% by a consecutive method, which includes aza-Wittig reaction of iminophosphorane 3 with aromatic isocynate to give carbodiimide 4 and subsequent reaction of 4 with various amines, phenols or alcohols in the presence of catalytic amount of sodium ethoxide or solid potassium carbonate. 2009 Ming Wu Ding. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.5,6-Dihydrothieno[3＇,2＇：4,5]thieno[2,3-d]pyrimidin-4（3H）-ones 6 were synthesized in yields of 71-87% by a consecutive method, which includes aza-Wittig reaction of iminophosphorane 3 with aromatic isocynate to give carbodiimide 4 and subsequent reaction of 4 with various amines, phenols or alcohols in the presence of catalytic amount of sodium ethoxide or solid potassium carbonate. 2009 Ming Wu Ding. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关 键 词：5 6-Dihydrothieno[3r 2＇：4 5]thieno[2 3-d]pyrimidin-4（3//）-one IMINOPHOSPHORANE Aza-Wittig reaction CARBODIIMIDE Isocyanate 

分 类 号：O626.12[理学—有机化学] TQ252.4[理学—化学]