An efficient Biginelli one-pot synthesis of new benzoxazole-substituted dihydropyrimidinones and thiones catalysed by trifluoro acetic acid under solvent-free conditions  

作　　者：D.Shobha M.Adharvana Chari K.H.Ahn 

机构地区：[1]Department of Applied Chemistry,Kyung Hee University,Suwon,Yongin-si,South Korea

出　　处：《Chinese Chemical Letters》2009年第9期1059-1061,共3页中国化学快报（英文版）

摘　　要：An efficient synthesis of benzoxazole-substituted 3,4-dihydropyrimidinones （DHPMs） using trifluoro acetic acid as the catalyst for the first time from an aldehyde, 13-keto ester and benzoxazole-substituted urea/thiourea under solvent-free conditions is described. Compared to the classical Biginelli reaction conditions, this new method consistently has the advantage of excellent yields （80-91%） and short reaction time （40-130 min） at reflux temperature. 2009 M. Adharvana Chad. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.An efficient synthesis of benzoxazole-substituted 3,4-dihydropyrimidinones （DHPMs） using trifluoro acetic acid as the catalyst for the first time from an aldehyde, 13-keto ester and benzoxazole-substituted urea/thiourea under solvent-free conditions is described. Compared to the classical Biginelli reaction conditions, this new method consistently has the advantage of excellent yields （80-91%） and short reaction time （40-130 min） at reflux temperature. 2009 M. Adharvana Chad. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关 键 词：DIHYDROPYRIMIDINONES Trifluoro acetic acid Benzoxazole-substituted urea and thiourea 

分 类 号：O621.2[理学—有机化学]