First total synthesis of two nematicidal prenylated flavanones  

作　　者：Jin Hui Yang Shi Zhi Jiang Yan Min Zhao Yun Feng Li Cong Bin Ji Wan Yi Liu 

机构地区：[1]Key Laboratory of Energy Resources and Chemical Engineering of Ningxia, Ningxia University, Yinchuan 750021, China

出　　处：《Chinese Chemical Letters》2009年第9期1062-1064,共3页中国化学快报（英文版）

基　　金：the National Natural Science Foundation(No.20562010);Ministry of National Education(No.203143)for financial support

摘　　要：The total synthesis of （＋）-8-（3-methylbut-2-enyl）-2-phenyl-2,3-dihydrochromen-4-one and （±）-2-（4-hydroxyphenyl）-8-（3- methylbut-2-enyl）-2,3-dihydrochromen-4-one was first achieved through C-prenylation, protection of phenolic hydroxyl group, aldol condensation, cyclization and deprotection starting from cheap benzaldehyde, 4-hydroxybenzaldehyde and 2-hydroxyace- tophenone, with total yield of 20 and 16.3%. All structures of new compounds were confirmed by IR, 1H NMR and MS. 2009 Jin Hui Yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.The total synthesis of （＋）-8-（3-methylbut-2-enyl）-2-phenyl-2,3-dihydrochromen-4-one and （±）-2-（4-hydroxyphenyl）-8-（3- methylbut-2-enyl）-2,3-dihydrochromen-4-one was first achieved through C-prenylation, protection of phenolic hydroxyl group, aldol condensation, cyclization and deprotection starting from cheap benzaldehyde, 4-hydroxybenzaldehyde and 2-hydroxyace- tophenone, with total yield of 20 and 16.3%. All structures of new compounds were confirmed by IR, 1H NMR and MS. 2009 Jin Hui Yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关 键 词：Nematicidal Fiavanone Isoprenylflavanoids Total synthesis 

分 类 号：O629[理学—有机化学] O629.9[理学—化学]