异福酰胺胶囊及片剂增加异烟肼和吡嗪酰胺的溶出度检查  

Supplement of the Dissolution Test of Isoniazid and Pyrazinamide in Isoniazid,Rifampin and Pyrazinamide Capsules and Tablets

作　　者：李冰[1] 傅蓉[1] 赵晓冬[1] 孙永超[1] 

机构地区：[1]辽宁省食品药品检验所,辽宁沈阳110023

出　　处：《中国医药工业杂志》2009年第9期691-694,共4页Chinese Journal of Pharmaceuticals

摘　　要：建议异福酰胺胶囊及片剂的溶出度检查方法中增加对异烟肼和吡嗪酰胺的考察,并建立了UV法测定该胶囊及片剂中的利福平、HPLC法分别测定该胶囊及片剂中的异烟肼和吡嗪酰胺。结果表明,利福平、异烟肼和吡嗪酰胺分别在16～40μg/ml、12.2～30.8μg/m1和38.7～117μg/ml浓度范围内,线性关系良好。三组分的方法回收率为99.4%～100.4%,RSD均小于0.55%。The suggestion was presented about addition of dissolution determination of isoniazid and pyrazinamide in isoniazid, rifampin and pyrazinamide compound capsules and compound tablets. An UV method was established for determination of rifampin, and an HPLC method was established for determination of isoniazid and pyrazinamide. The calibration curves of rifampin, isoniazid and pyrazinamide were linear in the concentration ranges of 16 - 40 μg/ml, 12.2 - 30.8μg/ml and 38.7 - 117μg/ml. The average recoveries were 99.4% - 100.4%, RSDs were less than 0.55 %.

关 键 词：利福平 异烟肼 吡嗪酰胺 胶囊 片剂 高效液相色谱 紫外分光光度 溶出度 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.72[化学工程—制药化工]