噻托溴铵与沙美特罗替卡松对慢性阻塞性肺疾病稳定期疗效比较  

Comparision of Therapeutic Effects between Tiotropium Bromide and Salmeterol/Fluticasone Propionate on Stationary Phases of Chronic Obstructive Pulmonary Disease

作　　者：刘漪[1] 戴百章[1] 吴进[1] 谢作舟[1] 吴涛[1] 

机构地区：[1]昆明市第一人民医院呼吸内科,650011

出　　处：《医药导报》2009年第9期1149-1151,共3页Herald of Medicine

摘　　要：目的评价噻托溴铵与沙美特罗替卡松对慢性阻塞性肺疾病(COPD)稳定期疗效。方法采用随机平行对照研究,将筛选合格的稳定期中重度COPD患者68例随机分为A、B两组,各34例。分别给予吸入噻托溴铵和沙美特罗替卡松粉剂。比较二者在治疗前、治疗后2及4周肺功能中一秒钟用力呼气量(FEV1)和一秒钟用力呼气量和用力肺活量比值(FEV1/FVC)的改变。结果68例受试者最终完成试验55例,其中A组25例,B组30例。治疗后二组肺功能均有明显改善;St George’呼吸问卷得分值降低,生活质量上升。B组患者依从性较好,稳定期内急性发作次数明显减少。结论噻托溴铵和沙美特罗替卡松粉剂对中重度慢性阻塞性肺疾病患者的肺功能及生活质量改善疗效均较好。沙美特罗替卡松粉剂患者依从性较好。Objective To compare therapeutic effects between tiotropium bromide and salmeterol/ fluticasone propionate on stationary phases of chronic obstructive pulmonary disease （COPD）. Methods A randomized and parallel comparison was conducted in 68 eligible patients with stable moderate to severe COPD, whom were randomized into two groups, inhaling tiotropium bromide as group A and inhaling salmeteroL/ fluticasone propionate as group B. To compare the value of FEV1 and FEV1/FVC before treatment and 2- week , 4-week after treatment. Results 55 patients completed clinical trial,including 25 cases inhaling tiotropium bromide and 30 cases inhaling salmeterol/fluticasone propionate. The lung function was significantly improved in two groups before and after treatment. The score in St George ＂respiratory questionnaire, and living qulity was elevated. The patients inhaling salmeteroL/ fluticasone propionate showed better compliance than those inhaling tiotropium bromide, and got less acute episodes, while aggravated infection. Conclusion Both inhalation of salmeterol/ flutieasone propionate and inhalation of tiotropium bromide have good therapeutic effects on lung function and life quality of patients with COPD at stationary phases. The patients inhaling salmeterol/ fluticasone propionate show better compliance than those inhaling tiotropium bromide, but may develop more infection.

关 键 词：噻托溴铵 沙美特罗替卡松 肺疾病 阻塞性 慢性 

分 类 号：R974[医药卫生—药品] R563[医药卫生—药学]