参一胶囊联合化疗治疗非小细胞肺癌的系统评价  

Treat Non-small Cell Lung Cancer with Shenyi Capsule plus Chemotherapy:A Systematic Review

作　　者：朱际平[1] 于力克[1] 郝可可[1] 张宇[1] 孙子凯[2] 

机构地区：[1]南京市胸科医院呼吸一科,江苏南京210046 [2]江苏省中医院呼吸科,江苏南京210029

出　　处：《辽宁中医杂志》2009年第9期1444-1447,共4页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的：系统评价参一胶囊联合化疗治疗非小细胞肺癌的安全性和有效性。方法 利用用计算机和手工方式检索中国期刊全文数据库（CNKI），中文科技期刊全文数据库、PubMed和Cochrane图书馆。检索参一胶囊联合化疗治疗非小细胞肺癌的随机对照临床研究。3位研究者对文献质量进行独立的评价，由Cochrane Collaboration’s software RevMan5．0．1进行Meta分析。结果：共有7项研究被纳入本系统评价，纳入病例535例。Meta分析显示参一胶囊联合化疗治疗非小细胞肺癌与单纯化疗相比，化疗缓解率显著增高（PetoOdds Ratio=2．25，95％CI=1．68—3．76），显著改善患者KPS评分（PetoOdds Ratio=3．57，95％CI：2．19～5．83），延长患者的中位生存期（MD=2．98，95％CI=1．02—4．94）。化疗的毒副反应两组基本相同。结论：参一胶囊联合化疗治疗非小细胞肺癌比单纯化疗有效，不增加化疗的毒副反应。这一证据需要更大规模的多中心随机临床对照研究进一步验证。Objective： To evaluate the efficacy and safety of shenyi capsule plus chemotherapy treated NSCLC. Methods ： We searched the CNKI, PubMed, VIP, and Cochrane Library up to the year of 2008. Manual search and additional search were also conducted. Randomized controlled trials of shenyi capsule plus chemotherapy treated NSCLC were included. Three reviewers independ- ently extracted data from eligible studies and evaluated the quality of included studies. Meta-analysis was performed for the results of homogeneous studies by the Ceehrane Collaboration＇s software RevMan 5. 0. 17. Results ：7 researches were included in the system re- view. Total 535 patients were involved. Meta-analyses showed that shenyi capsule plus chemotherapy compared with chemotherapy is more effective in response rate （PetoOdds Ratio = 2. 25 95% CI = 1.68 ～3. 76）, KPS scale improved rate （ PetoOdds Ratio = 3.57, 95% CI = 2. 19 ～ 5. 83）, and median survival time （ MD = 2. 98 95 % CI1.02 ～ 4. 94）. The adverse reaction of chemotherapy was similar between two groups. Conclusion：Shenyi capsule plus chemotherapy has beneficial effects in treatment of NSCLC. Due to the poor quality and small sample of the included trials, more large-scale multi -center randomized trials are needed.

关 键 词：参一胶囊 非小细胞肺癌 化疗 META分析 

分 类 号：R734.2[医药卫生—肿瘤]