新型骨修复材料复合掺杂聚磷酸钙的降解、矿化及力学性能研究  

The research on degradability,mineralization and mechanical properties of co-substituted calcium polyphosphate as a new kind of bone repair material

作　　者：王启光[1] 宋巍[1] 汪前彬[1] 张小华[1] 余喜讯[1] 万昌秀[1] 

机构地区：[1]四川大学高分子科学与工程学院,四川成都610065

出　　处：《功能材料》2009年第9期1506-1509,1512,共5页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(30870614;30870616);四川省应用基础研究资助项目(07JY029-075)

摘　　要：用复合掺杂方法改性一种新型骨修复材料聚磷酸钙(CPP)以期综合提高材料的理化性能,其中的掺杂元素有钾(K)、钠(Na)和锶(Sr)。通过X射线衍射分析(XRD)表征复合掺杂后材料的晶体结构并通过等离子发射光谱(ICP)分析掺杂后CPP内主要元素含量。以生理盐水为降解介质,通过失重法,钼蓝分光光度法和EDTA-钙红绿素滴定法分析材料的降解性能。用扫描电镜(SEM)观察在PBS矿化介质中浸泡样品的表面形貌,定性描述表面矿化沉积物的情况。通过检测多孔材料的抗压强度表征其力学性能。结果表明,复合掺杂改性不同程度地提高了材料的降解、矿化和力学性能,NSCPP和KSCPP材料相对于单一掺杂材料具有更显著的优势。In order to improve the physical and chemical properties of calcium polyphosphate （CPP） synthetically, the method of co-substituted is used in this study and the doped elements are kalium, natrium, strontium. XRD was used to observe the changes in the structure of crystals after doping and ICP was used to analysis the content of the main elements in doped CPP. Using saline as the degradation medium, the common rate of degradation was evaluated by weight-loss method, molybdenum-blue spectrophotometry and EDTA-C30H24 N2Na2 O13 titration method. In order to describe the surface sediments of mineralization qualitatively, scanning electron microscopy （SEM） was used to reveal the surface of materials which had immersed in PBS solution for some days. And the compressive strength was tested to receive the mechanical strength. It was suggested that the cosubstituted materials are better in degradation, mineralization and mechanical properties in different degrees and KSCPP and NSCPP have more excellent properties than the single-doped materials.

关 键 词：聚磷酸钙 复合掺杂 降解 矿化 力学性能 

分 类 号：O611.65[理学—无机化学]