矽肺疗效评价中生化指标的应用及分析总结  

Application and Analysis of Biochemical Indices for the Evaluation of Antisilicosis Treatment Study on Anti Silicosis Therapy and its Evaluation Research Grou

作　　者：刘秉慈[1,2] 秦孝发 

机构地区：[1]中国预防医学科学院劳动卫生与职业病研究所 [2]北京医科大学公共卫生学院

出　　处：《卫生研究》1998年第4期222-224,共3页Journal of Hygiene Research

基　　金："八.五"国家科技攻关项目

摘　　要：对２９６例矽肺患者分组进行了由汉防己甲素（汉甲）、克矽平、抗矽一号＋柠檬酸铝（柠铝）组成的３种联合用药方案的矽肺治疗，在疗前及第１，３，６疗程后测定血清铜蓝蛋白（Ｃｐ）、超氧化物岐化酶（ＳＯＤ）和ＩｇＧ含量。同时观察对照病人１４４例。发现三项指标在治疗后有总体下降趋势。ＳＯＤ在治疗中有波动，即第１疗程后下降，第３疗程后上升，第６疗程后又回落。Ｃｐ、ＳＯＤ及ＩｇＧ的下降与药物的临床疗效符合。表明Ｃｐ、ＳＯＤ及ＩｇＧ是较为理想的生化指标。检验过程中的质量控制及统计分析时的标化处理。he levels of serum Ceruloplasmin (Cp), Superoxide dismutase (SOD) and IgG of 296 silicosis patients treated by tetrandrine, polyvinylpridine N Oxide, hydroxypiperaquinoline phosphate and aluminium citrate were measured.Sera were collected before and after the lst, 3rd and 6th therapy courses. 144 silicosis patients without treatment were observed as controls. The levels of these three indices decreased by the end of treatment. The levels of SOD were fluctuated, which were increased after the 3rd course, but decreased after the 1st and 6th courses. The decrease of Cp, SOD and IgG consisted with the clinical effectiveness of the treatment,indicating that Cp, SOD and IgG were appropriate biochemical indicators for the evaluation of antisilicosis drugs. The quality control and the statistics standardization for data analysis are important.

关 键 词：矽肺 药物疗法 汉防己甲素 克矽平 生化指标 

分 类 号：R135.2[医药卫生—劳动卫生]