锰对大鼠子代生长发育的影响  

Effect of Manganese on the Growth and Development of Rat Offspring

作　　者：张德兴[1] 贺新红[1] 张文光[1] 檀进发[2] 黄绍明[2] Pappas BA 

机构地区：[1]广东药学院基础学科部 [2]广西医科大学解剖学教研室 [3]加拿大卡尔顿大学生命科学研究中心

出　　处：《卫生研究》1998年第4期237-240,共4页Journal of Hygiene Research

基　　金：国家自然科学基金

摘　　要：观测了经口染锰对大白鼠子代生长发育的影响。结果显示：（１）高剂量组仔鼠的体重显著下降，但脑重／体重比值却明显升高；（２）在Ｍｏｒｒｉｓ水迷宫试验中，高剂量组仔鼠前５天每天到达潜台的潜伏期显著缩短；在第６天无潜台探测试验中，其在原潜台象限的游泳长度明显增长，但游泳的总长度与对照组和低剂量组之间却无差异；（３）染锰组，特别是高剂量组仔鼠海马的胶质细胞纤维酸蛋白免疫反应强度和免疫反应阳性产物的平均相对密度。Effects of Manganese exposure to pregnant rats on the growth and development of their offsprings were as follows:(1) the gain of body weight and brain weight in the high dose Mn exposed offspring was significantly lower but the ratio of brain to body weight was significantly higher; (2) in Morris Water Maze Test, the average latency to find the hidden platform in the high dose Mn exposed offsprings was obviously reduced during the first 5 days. But on the non platform test day, a much longer length of swimming in the quadrant in which the hidden platform was located previously, although no difference was found for the total distance between them; (3) the immunoreactivity of glial fibrillary acid protein and the average density of its products in hippocampus of both the low and high dose Mn exposed groups, especially of the high dose one, was significantly higher than that of the control group.

关 键 词：锰 子代 生长发育 

分 类 号：R135.1[医药卫生—劳动卫生] Q344.5[医药卫生—公共卫生与预防医学]