依那普利联用糖皮质激素治疗特发性肺纤维化  

Cinical Effect of IPF Treated by Combination of Enalapril and Prednisone

作　　者：于磊[1] 李勇[2] 

机构地区：[1]河南省安阳市人民医院呼吸内科,安阳市455000 [2]河南省濮阳市安阳地区医院呼吸内科,濮阳市457000

出　　处：《医药论坛杂志》2009年第16期28-29,共2页Journal of Medical Forum

摘　　要：目的观察依那普利(Enalapril)联用糖皮质激素对特发性肺纤维化的治疗作用。方法将64例特发性肺纤维化患者随机分为2组,对照组32例(P组)口服强的松,观察组32例(P+E组)口服依那普利联用强的松),两组疗程均为6个月。观察临床症状、肺CT、肺功能改变。结果观察组在有效率、改善症状、肺功能、血气分析方面均优于对照组(P<0.05)。结论依那普利联用糖皮质激素是一种有较好前景的治疗肺纤维化的方法。Objective To investigat the clinical effect of idiopathic pulmonary fibrosis （IPF） treated by combination of Enalapril and Prednisone. Methods Total 64 case were randomly divided into two groups： control group and combination of Enalapril with Prednisone group. Control group were given Prednisone for 6 month. Combination of Enalapril with Prednisone group were given Telmisartan and Prednisone for 6 month. To observe the change of clinical symptom, lung CT, blood gas analysis and pulmonary function. Results Combination of Enalapril with Prednisone group were significant improvement in efficiency, symptom, lung CT and pulmonary function than that of control group （P 〈 0. 05）. Conclusion The Telmisartan has accessory treatment function of anti - fiberosis, thus providing another new way to cure idiopathic pulmonary fibrosis.

关 键 词：特发性肺纤维化 依那普利 糖皮质激素 

分 类 号：R563.9[医药卫生—呼吸系统]