电磁脉冲对小鼠学习记忆和探究反射的影响  

EFFECTS OF ELECTROMAGNETIC PULSE (EMP) ON THE ABILITY OF LEARNING AND MEMORY AND INVESTIGATORY REFLEX OF MICE

作　　者：吴彦卓[1] 贾宇峰[1] 郭鹞[1] 郑振兴[2] 周晏[2] 

机构地区：[1]第四军医大学放射医学教研室 [2]西北核技术研究所

出　　处：《解放军预防医学杂志》1998年第3期170-172,共3页Journal of Preventive Medicine of Chinese People's Liberation Army

摘　　要：为了观察电磁脉冲（ＥＭＰ）对小鼠学习记忆和探究反射的影响，采用经典的Ｙ型迷路法和改良的开阔法（ｏｐｅｎｆｉｅｌｄｍｅｔｈｏｄ），检测三种电场强度的ＥＭＰ辐照后１ｄ内、１周和４周三个时间点小鼠学习记忆和探究反射。结果发现，与对照组相比，辐照后１周４０ｋＶ·ｍ１组小鼠学习和记忆成绩降低（Ｐ＜０．０５），８０ｋＶ·ｍ１组小鼠学习成绩降低（Ｐ＜０．０５）；与对照组比较，辐照后１天内三种电场强度辐照组小鼠探究反射均下降（Ｐ＜０．０５），以４０ｋＶ·ｍ－１组更明显。辐照后１周８０ｋＶ·ｍ１组小鼠探究反射下降（Ｐ＜０．０５）。由此可见，电磁脉冲可能影响小鼠的学习记忆和探究能力。The effects of electromagnetic pulse (EMP) on the ability of learning and memory and investigatory reflex of mice were observed. The mice were randomly divided into four groups: normal control, 8 kV·m 1 ,40 kV·m 1 ,and 80 kV·m 1 .Using classical Y-maze method and improved open field method, we measured the ability of learning and memory and investigatory reflex of mice in each group respectively in l d, l wk, and 4 wk after exposure. Compared with control group, l wk after exposure, the ability of learning and memory of mice in 40 kV·m 1 group decreased (P<0.05),and the ability of learning in 80 kV·m 1 also reduced (P<0.05). l d after exposure, the investigatory reflex of all the three exposed groups was lower than that of control group (P<0.05),especially that of 40 kV·m 1 group. l wk after exposure, only the investigatory reflex of 80 kV·m 1 group was lower (P<0.05) than that of control . It can be concluded that 8 kV·m 1 , 40 kV·m 1 and 80 kV·m 1 EMPs can affect the ability of learning and memory and investigatory reflex of mice.

关 键 词：电磁脉冲 学习 记忆 探究反射 

分 类 号：R454.1[医药卫生—治疗学] R338.64[医药卫生—临床医学]