针灸对SAMP8小鼠嗅球神经干细胞向胶质细胞分化的影响  

Influence of acupuncture and moxibustion on neural stem cells differentiated into glial cell in senescence-accelerated mouse P8 olfactory bulb

作　　者：尹海燕[1] 乔秀兰[2] 卢圣锋[1] 曾芳[1] 吴巧凤[1] 魏焦禄[1] 黄梅[1] 余曙光[1] 唐勇[1] 

机构地区：[1]成都中医药大学针灸推拿学院,成都610075 [2]重庆市中医院,重庆400013

出　　处：《成都医学院学报》2009年第3期173-176,共4页Journal of Chengdu Medical College

基　　金：国家自然科学基金(90709032);四川省青年科技基金(09ZQ026-025);国家重点基础研究发展计划(2006CB504501;2009CB522903);四川省教育厅课题(200ZD004)资助

摘　　要：以SAMP8快速老化小鼠作为研究对象,采用BrdU/S-100β、BrdU/GALC免疫荧光双标探讨针刺、艾灸治疗对嗅球神经干细胞向星形胶质细胞和少突胶质细胞分化的影响。研究结果表明,艾灸可能抑制SAMP8小鼠嗅球NSCs向星形胶质细胞和少突胶质细胞分化,但针刺刺激主要是抑制SAMP8小鼠嗅球NSCs向星形胶质细胞分化,而对向少突胶质细胞分化抑制作用不明显。We used immunofluorescence double staining methods（BrdU/S-100 Band BrdU/GALC） to identify neural stem cells differentiation in olfactory bulb of senescence-accelerated mouse P8 after acupuncture and moxibustion therapy performed. The results showed that both acupuncture and moxibustion could inhibit neural stem cells from differentiating into astrocyte but only moxibustion could inhibit neural stem cells from differentiating into oligodendrocyte.

关 键 词：针灸疗法 嗅球 神经干细胞 胶质细胞 分化 

分 类 号：R245[医药卫生—针灸推拿学]