快释型磷酸钙骨水泥性能和释药机理  

PROPERTIES AND DRUG RELEASE MECHANISM OF FAST-RELEASING CALCIUM PHOSPHATE CEMENT

作　　者：李茂红[1,2] 屈树新[2] 姚宁[2,3] 冯波[2] 郭悦华[2] 王岳峰[1] 

机构地区：[1]西南交通大学峨眉校区基础课部,四川峨眉614202 [2]西南交通大学材料科学与工程学院,材料先进技术教育部重点实验室,成都610031 [3]西南交通大学生命科学与工程学院,成都610031

出　　处：《硅酸盐学报》2009年第9期1500-1505,共6页Journal of The Chinese Ceramic Society

基　　金：西南交通大学峨眉校区基金(10801X10096010);教育部新世纪人才基金(NCET–05–0797);国家自然科学基金(30470484)资助项目

摘　　要：磷酸钙骨水泥(calcium phosphate cement,CPC)是一种具有临床应用前景的抗生素载体材料,但抗生素长期残留易导致发生耐药性,本研究的目的是制备和表征快释型磷酸钙骨水泥(fast-releasing calcium phosphate cement,FRCPC),并研究其快速释放机理。采用在CPC中加入易溶于水的物质制备FRCPC,测试其凝结时间、抗压强度、药物体外释放及释放过程中易溶于水的物质的溶出,观察骨水泥断面微观形貌。结果表明:FRCPC初凝时间为(8±0.33)min,终凝时间为(16±0.50)min,抗压强度为(2.6±0.23)MPa。药物体外释放结果表明:FRCPC中的药物释放明显快于CPC中的,能在7d内完全释放。在药物释放不同时间点的X射线衍射谱和采用沉淀滴定法测试易溶于水的物质溶出量的结果均表明:FRCPC中,易溶于水的物质迅速溶出,与扫描电镜观察结果(FRCPC相对于CPC孔隙率增加和孔径增大)相吻合,利于FRCPC中药物快速释放;且释放符合以扩散控释为主的Higuchi模型。FRCPC可实现防止耐药性发生的目的,通过进一步性能改进有望应用于临床。Calcium phosphate cement（CPC） is a promising antibiotic carrier in clinical use,but the long-term retention of antibiotic in the cement may cause the development of drug resistance. Therefore,the objective of this study is to prepare a fast-releasing CPC（FRCPC） and characterize its material properties and in vitro drug release mechanism. The FRCPC was prepared by incorporation of a soluble component into CPC. The setting time,compressive strength,in vitro drug release,dissolution of the soluble component, and the morphology of the fracture surface were studied. The FRCPC shows initial and final setting times of （8±0.33） min and （16±0.50） min, and a compressive strength of （2.6±0.23） MPa. The in vitro release from the FRCPC is completed within 7 d, which is significantly faster than the control CPC. X-ray diffraction and the dissolution quantity of the soluble component which was deter- mined by the precipitation titration found a rapid dissolution of the soluble component during the in vitro release, and scanning eLec- tron microscope results reveal a higher porosity and larger pore size compared with the control CPC. These observations all indicate an accelerated drug release. The release kinetics follow Higuchi＇s diffusion control model. The FRCPC may prevent the development of drug resistance and may be used in clinical applications.

关 键 词：磷酸钙骨水泥 快释 性质 释药机理 孔隙率 

分 类 号：O614.23[理学—无机化学] R944[理学—化学]