山西农村地区妇女HPV-6、11、16、18的血清流行病学研究  

Serological epidemiology study of HPV-6, 11,16,18 in Shanxi rural women

作　　者：王建炳[1,2] 胡尚英[2] 王鹤[2] 陈汶[2] 马俊飞 苏采峰 李志霞 武燕萍[2] 乔友林[2] 

机构地区：[1]中国医学科学院基础医学研究所北京协和医学院基础学院流行病学教研室,北京100005 [2]中国医学科学院肿瘤研究所流行病学室,北京100021 [3]山西省襄垣县妇幼保健院

出　　处：《中华微生物学和免疫学杂志》2009年第8期701-705,共5页Chinese Journal of Microbiology and Immunology

基　　金：基金项目：美国克里夫兰医学中心资助项目

摘　　要：目的研究中国农村地区妇女HPV-6、11、16、18型抗体分布情况，为将来HPV疫苗在中国的应用提供一定的依据。方法采用横断面研究的方法，调查山西襄垣县年龄为19～54岁妇女884名。问卷收集人口统计学指标、疾病史、月经史等信息。荧光检测法检测静脉血HPV-6、11、16、18血清型抗体。结果山西农村地区妇女HPV-6、11、16、18病毒样颗粒（VLP）抗体阳性率分别为7．35％、2．26％、6．90％、1．58％。任意一种HPV-6、11、16、18VLP抗体阳性率为14．93％。子宫颈病变正常、宫颈上皮内瘤变（CIN）1级及CIN2＋妇女的HPV．16VLP抗体阳性率分别为5．36％、14．63％、50．00％（P〈0．0001）。性伴侣数为1〉2的妇女HPV-6／11和HPV-16／18VLP抗体阳性率均高于性伴侣数为1组，且差异有统计学意义（P〈0．05）。HPV-6／11、16／18VIJP抗体与首次性行为年龄、吸烟、教育程度和避孕套使用情况均无统计学关联。结论HPV-6、16型在山西襄垣被调查妇女中感染较普遍，CIN2及以上病变的患者中有一半感染过HPV-16型。HPV-16VLP抗体阳性率与子宫颈病变程度有关，且随病变程度的加重而增加。Objective To evaluate the distribution of HPV-6, 11, 16, 18 virus-like particle（VLP） antibodies in Chinese women population in rural area and provide data for implementation of the prophylactic HPV vaccines in China. Methods A cross-sectional study was conducted to interview 884 women aged 19-54 living in Shanxi, China. Questionnaire data, including demography, disease history and menstrual history were collected between 2006 and 2007. HPV-6, 11, 16, 18 antibodies in venous blood were detected by Merck Re- search Laboratory using fluorescence method. Results Positive rate of HPV-6, 11, 16, 18 VLP antibodies among women in Xiangyuan, Shanxi were 7.35%, 2.26% , 6.90%, 1.58% , respectively. Positive rate of any type of HPV-6, 11, 16, 18 VLP antibodies was 14.93%. HPV-16 VLP antibodies of women with normal, cer- vical intraepithelial neoplasia（CIN） 1 and CIN2 ＋ lesions were 5.36% , 14.63% , 50.00% , respectively, which was statistical significance using Cochran-Armitage tendency test （ P 〈 0.0001 ）. The seroprevalences of HPV-6/11, HPV-16/18 were much higher in women who had 2 or more lifetime sex partners than those women who had 1 lifetime sex partner（ P 〈 0.05 ）. HPV-6/11 and 16/18 VLP antibodies were not statistically associat- ed with age at first sexual intercourse, smoking status, education and condom using status. Conclusion HPV- 6 and HPV-16 were the most two popular HPV types in the whole population, while HPV-16 was the most com- mon type in CIN2 ＋ population. HPV-16 seroprevalence increased with severity of cervical intraepithelial neo- plasia.

关 键 词：人乳头瘤病毒抗体 血清流行病学 荧光检测法 

分 类 号：R181.3[医药卫生—流行病学]