肾综合征出血热患者血清IL-6测定的临床意义  

Clinical significance of serum interleukin 6 levels in patients with hemorrhagic fever with renal syndrome

作　　者：樊万虎[1] 张帆[1] 岳金声[1] 朱风群[1] 

机构地区：[1]西安医科大学第一临床医学院

出　　处：《细胞与分子免疫学杂志》1998年第1期51-53,共3页Chinese Journal of Cellular and Molecular Immunology

摘　　要：应用双抗体夹心ＥＬＩＳＡ法、放射免疫测定法和间接免疫荧光测定法，同步检测了４８例ＨＦＲＳ患者血清ＩＬ６，β２ＭＧ，特异性ＩｇＭ和ＩｇＧ的动态变化。结果表明，ＨＦＲＳ患者血清ＩＬ６水平发热期已高于正常组（Ｐ＜００１），并达较高水平，少尿期达高峰，与临床病情的进展相一致；ＩＬ６、特异性ＩｇＭ和ＩｇＧ分别于病程的第６ｄ，第９ｄ及第１１ｄ达高峰，ＩＬ６与血清球蛋白呈明显的正相关，ＩＬ６与ＨＦＲＳ患者病程中特异性抗体的升高有明显关系；轻、中、重和危重型患者血清ＩＬ６与ＩｇＧ间呈正相关，且ＩＬ６随病情加重而升高。提示：ＩＬ６可能与体液免疫功能亢进所致免疫病理损伤有关，并根据ＩＬ６与血清β２ＭＧ，尿素氮（ＢＵＭ）和肌酐（Ｃｒ）均呈高度正相关，表明ＩＬ６参与了肾脏的免疫损伤。The dynamic changes of serum interleukin 6 (IL 6), β 2 microglobulin (β 2 MG) and specific IgM and IgG levels were determined in 48 patients with hemorrhagic fever wth renal syndrome (HFRS) using double antibody sandwich ELISA, radioimmunoassay and indirect immunofluorescence technique separately. The resusts showed that serum IL 6 levels in HFRS patients increased significantly compared with normal controls ( P <0.01) at fever stage, peaked at oliguria stage and were consistent with the course of the clinical severity. IL 6, specific IgM and IgG in HFRS patients reached peak levels at day 6, day 9 and day 11 after onset of illness respectively. serum IL 6 levels were positively related to the serum globulin levels and had remarkable relateonship with the increase of specific antibodies. The positive relationships between serum IL 6 and IgG in mild, middle, severe and gravis types of HFRS patients and the increase of IL 6 levels along with the severity of disease indicated that Il 6 was associated with the immunopathological lesions caused by the hyperfunction of humoral immune respense. The close positive associations between IL 6 and serum β 2 MG, BUN and creatinine suggested that IL 6 participated the renal immune impairment in patients with HFRS.

关 键 词：肾综合征出血热 Β2-微球蛋白 白细胞介素6 测定 

分 类 号：R512.8[医药卫生—内科学]