PD-1/PD-L对免疫调节作用的研究进展  

Role of PD-1/PD-L in regulating immune responses

作　　者：陈姬[1] 王贵强[1] 

机构地区：[1]北京大学第一医院,北京100034

出　　处：《传染病信息》2009年第4期240-243,共4页Infectious Disease Information

基　　金：国家自然科学基金项目(30771905)

摘　　要：程序性死亡分子1(programmed death-1,PD-1)/PD-1的配体(programmed death ligand,PD-L)属于抑制性共刺激分子,能对免疫反应的产生起负调节作用。PD-1在慢性感染性疾病中的功能缺陷型CD8+T细胞上高表达,导致功能性CD8+T细胞的功能受损,包括细胞增殖、细胞因子分泌和杀伤能力。在肿瘤、自身免疫性疾病和感染性疾病中,PD-1/PD-L参与免疫反应的调节,抑制抗瘤及抗病毒免疫反应,阻断此通路后可以恢复特异性CD8+T细胞的部分功能,因此,PD-1/PD-L通路可能与肿瘤细胞免疫逃避和病毒感染疾病慢性化有关。PD-1/PD-L, a member of costimulatory molecules, can play a role of negatively regulating immune responses. High-level expression of PD-1 on dysfunctional CD8^＋ T cells in chronic infectious diseases leads to functional impairment of CD8^＋ T cells, in terms of cell proliferation, secretion of cytokines and cytotoxic capacity. In tumor diseases, autoimmune diseases and infectious diseases, PD-1/ PD-L is involved in the regulation of immune responses and suppresses anti-tumor and antiviral immune responses, so that blockeade of the pathway is able to restore partial functions of specific CD8^＋ T cells. Therefore, PD-1/PD-1 pathway may be associated with immune response evasion of tumor cells and chronic progression of viral infection.

关 键 词：PD-1 PD—L 免疫应答 

分 类 号：R392[医药卫生—免疫学]