人参茎叶皂甙对口蹄疫病毒灭活疫苗免疫后抗体产生的影响  

Effects of ginsenosides of stems and leaves on immune response to foot and mouth disease attenuated virus vaccine

作　　者：包省军[1] 宋小明[1] Kedsirin Sakwiwatkul 曹立亭[1] 吴丽华[1] 潘春刚 王洪海 李杰 胡松华[1] 

机构地区：[1]浙江大学动物科学学院,浙江杭州310029 [2]中牧实业股份有限公司,北京100094

出　　处：《中国兽医学报》2009年第9期1103-1105,共3页Chinese Journal of Veterinary Science

基　　金：科技部科技支撑计划资助项目(2008BADB4B06-2);浙江省科技厅资助项目

摘　　要：分别用人参茎叶皂甙(GSL)、白油或两者混合物作为免疫佐剂,与Asia-Ⅰ型口蹄疫病毒(FMDV)灭活疫苗混合免疫小鼠,检测免疫后的血清特异性抗体水平。结果表明,GSL具有佐剂作用,能显著促进机体产生抗FMDV抗体的水平,其佐剂作用呈量效关系。当GSL和白油混合形成复合佐剂时,具有组合效应,能产生比2种佐剂单独应用时更强的抗体效价;且GSL和白油混合产生的组合效应主要促进IgG2a和IgG2b的产生。ICR mice were injected with porcine foot and mouth disease （FMD） attenuated vaccine combined with ginsenosides of stems and leaves （GSL）, oil or GSL＋ oil. After vaccination, the blood samples were collected from the mice for determination of antibody responses. The results indicated GSL had significant adjuvant activities on the production of antibodies against FMD with dose dependent effect. Combination of GSL and oil promoted significantly higher antibody level than that of GSL or oil alone, especially in the production of IgG2a and IgG2b.

关 键 词：人参茎叶皂甙 白油 口蹄疫 疫苗 佐剂 

分 类 号：S852.4[农业科学—基础兽医学] S852.65[农业科学—兽医学]