腺苷蛋氨酸治疗病毒性肝炎高胆红素血症的疗效观察  

Observation of S-adenosylmethioninein in treating hyperbilirubinmia-virus hepatitis

作　　者：汤桂芳[1] 陈瑞玲[1] 袁霞[1] 

机构地区：[1]广西壮族自治区南溪山医院肝病科,广西桂林541002

出　　处：《华夏医学》2009年第3期388-390,共3页Acta Medicinae Sinica

摘　　要：目的:探讨腺苷蛋氨酸对病毒性肝炎高胆红素血症的治疗价值。方法:87例病毒性肝炎高胆红素血症患者随机分成两组,对照组予以甘利欣、门冬氨酸钾镁等综合基础治疗,治疗组在综合基础治疗的基础上加用腺苷蛋氨酸注射液,疗程为4周。治疗后对两组患者的血清ALT、TBil、PT水平和总有效率采用SPSS10.0统计软件包进行t检验及χ2检验进行比较。结果:治疗后两组各项指标明显低于治疗前(P<0.01),治疗组治疗后的ALT、TBil均比对照组治疗后明显下降,差异有极显著性(P<0.01),治疗组的总有效率显著高于对照组(P<0.01)。结论:腺苷蛋氨酸可有效治疗病毒性肝炎的高胆红素血症。Objective： To assess the value of S-adenosylmethioninein （SAM） in treating hyperbilirubinmia-virus hepatitis. Methods ： 87 cases of hyperbilirubinmia-virus hepatitis patients were randomly divided into treatment group and control group. The same basic therapy was given to the two groups. SAM was given to the treatment group for 4 weeks on the basic of routine therapy. The serum alanine aminotransferase, serum total bilirubin, prothrombin time, the total effective rate were analyzed using SPSS10. 0 statistical package χ^2 test and t test comparison after treatment. Results： Two indicators were significantly lower after treatment than before （P 〈 0. 01）. The improvement of serum alanine aminotransferase, serum total bilirubin in treatment group were more significant than those of the control group （P〈0.01）. The total effective rate （significant effect and effective） in treatment group was significantly higher than that of the control group （P〈0. 01）. Conclusion： SAM is an effective drug for the treatment of hyperbilirubinmia-virus hepatitis.

关 键 词：腺苷蛋氨酸 病毒性肝炎 高胆红素血症 

分 类 号：R512.6[医药卫生—内科学]