强心灵流浸膏治疗充血性心力衰竭的临床研究  

Clinical Study on Qiangxinling Liquid Extract in Treating Congestive Heart Failure

作　　者：林慧娟[1] 王翠萍[1] 郭伟星[1] 包培蓉[1] 蔡爱华[1] 

机构地区：[1]山东中医药大学附属医院,济南250011

出　　处：《中国中西医结合杂志》1998年第8期468-471,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：山东省卫生厅资助课题

摘　　要：目的 :为研究治疗充血性心力衰竭安全有效的药物和方法。方法 :对充血性心力衰竭心功能分级属Ⅲ～Ⅳ级的 90例患者随机分为 3组 ,每组 3 0例。A组服用强心灵流浸膏 ,B组服用强心灵流浸膏加小剂量地高辛 ,C组服用地高辛。结果 :心功能疗效 ,A组总有效率为 86 7% ,B组为 93 3 % ,C组为 83 3 % ,B组疗效优于A组及C组 (P <0 0 5 ,P <0 0 1 )。地高辛停减率 ,B组为 86 7% ,C组为 5 0 0 % ,两组比较有显著性差异 (P <0 0 5 )。A、B、C组治疗前后比较 ,均可改善左室收缩功能指标 ,包括每搏输出量 (SV)、每分钟心输出量 (CO)、射血分数 (EF) ,其中B组作用显著 (P <0 0 5 ,P <0 0 1 )。A、B组治疗前后比较 ,具有改善左室舒张功能作用 ,即改善舒张晚期最大血流速度 (A)、舒张早期最大血流速度 (E)、舒张晚期与舒张早期最大血流速度之比 (A/E)的作用 (P <0 0 5 ,P <0 0 1 )。A、B组治疗后血浆肾素活性(PRA)、血管紧张素Ⅱ (AngⅡ )、心钠素 (ANF)含量浓度与C组比较 ,亦有显著性差异 (P <0 0 5 ,P <0 0 1 )。结论 :强心灵流浸膏可改善心功能、临床症状和神经内分泌指标 ,并可降低洋地黄的毒副作用。Objective: To find the safe and effective treatment and drugs for congestive heart failure (CHF). Methods: Ninety CHF patients whose heart function belong to Ⅲ-Ⅳ grade were randomly divided into 3 groups: Group A was treated with Qiangxinling liquid extract (QXLLE); Group B with QXLLE plus small dose of digoxin and Group C with digoxin alone. Results: The total effective rate on heart function of Group A was 86.7%, Group B 93.3% and Group C 83.3%, the effect of Group B was better than that of the other two groups (P<0 05,P<0 01). The digoxin withdrawing and reducing rate in Group B was higher than that in Group C (86.7% vs 50 0%, P<0 05). The left ventricular systolic function, including stroke volume ,cardiac output, ejection fraction of the 3 groups were improved after treatment, among them the effect of Group B was the best (P<0 01). Moreover, improvement in ventricular diastolic function was shown in Group A and B, including the maximum blood flow of the late and the early diastolic stage as well as the ratio of them (P<0 05,P<0 01). The plasma renin activity, angiotensin Ⅱ and atrial natriuretic peptide of Group A and B were also lowered after treatment and were significantly different to those of the Group C (P<0 01). Conclusions: QXLLE could improve the heart function, clinical symptoms and neuro endocrinal indexes of CHF patients and reduce the side effects of digoxin.

关 键 词：强心灵流浸膏 充血性心力衰竭 中医药疗法 

分 类 号：R259.416.1[医药卫生—中西医结合]