水相合成CdX(X=Te,Te/CdS,Te/ZnS)红色量子点及毒性效应  

Aqueous Phase Synthesis of Red CdX(X=Te,Te/CdS,Te/ZnS) Quantum Dots and Their Toxic Effects

作　　者：王显祥[1,2] 黄娟[3] 靳茹文[3] 杨中科[3] 单志[1] 杨婉身[1] 

机构地区：[1]四川农业大学生命科学与理学院,雅安625014 [2]四川大学化学学院,成都610041 [3]四川农业大学动物医学院,雅安625014

出　　处：《化学学报》2009年第17期2025-2030,共6页Acta Chimica Sinica

基　　金：四川农业大学引进人才基金(No.007202);四川省教育厅自然科学科研重点(No.2005A033)资助项目

摘　　要：分别以巯基乙酸(Mercaptoacetic Acid,MA)、还原型谷胱甘肽(Glutathione,GSH)为稳定剂在水相中直接合成了巯基乙酸CdTe(CdTe-MA)、红色巯基乙酸CdTe/CdS(CdTe/CdS-MA)、巯基乙酸CdTe/ZnS(CdTe/ZnS-MA)及谷胱甘肽CdTe(CdTe-GSH)量子点.其中,CdTe-GSH量子点的量子产率可达47.3%.体外溶血实验证实CdTe/ZnS-MA和CdTe-GSH量子点的溶血率较CdTe-MA和CdTe/CdS-MA低,浓度为0.05mmol/L的量子点溶血率<5%,达到了生物医用材料的要求.活体实验证实:通过尾静脉方式把量子点注入小鼠体内后,荧光显微镜观察发现高剂量的量子点(0.4mmol/10g)在体内主要在心、肝、脾、肾组织中分布较多,且引起不同程度的组织病变.Mercaptoacetic acid （MA） capped CdTe, CdTe/CdS, CdTe/ZnS quantum dots （QD） and glutathione （GSH）-capped CdTe QDs were directly synthesized in aqueous media. The fabricated CdTe-GSH QDs have an ultra small hydrodynamic diameter （3--4 nm） and possess high quantum yields （47.3%）. In vitro hemolysis testing showed that the hemolysis rates （HR） of CdTe/ZnS-MA and CdTe-GSH were less than 5% （concentration being 0.05 mmol/L）, which were lower than CdTe-MA and CdTe/CdS-MA QDs, meeting the requirements for biomedical materials. The toxicity of QD in vivo was tested by injected QD in mice through tail vein. Fluorescence microscopy showed that a high dosage （0.4 mmol/10 g） of CdTe-GSH and CdTe/ZnS-MA QD was distributed mainly in the heart, liver, spleen and kidney tissues and caused varying degrees of tissue lesions.

关 键 词：红色量子点 溶血 毒性 谷胱甘肽 

分 类 号：O614.242[理学—无机化学]